Role of p120 Catenin in Epac1-Induced Chronic Postsurgical Pain in Rats

Figure 5

Effects of 8-pCPT on changes of MWT, vascular endothelial permeability, macrophages, endothelial cells, and the expression of p120 in muscle tissue around the incision. (a) MWT at the 1st, 3rd, 6th, and 12th hour in the 8-pCPT group was significantly lower, , , vs. saline group. (b) The vascular endothelial permeability of the 8-pCPT group at the 3rd and 6th hour was significantly increased, vs. saline group. (c) p120 was significantly decreased in the 8-pCPT group at the 3rd and 6th hour, vs. saline group. (d) The endothelial cells in the 8-pCPT group significantly increased at the 3rd and 6th hour, vs. saline group. (e) Macrophages in the 8-pCPT group significantly increased at the 3rd and 6th hour, vs. saline group. Data information (a–e) error bars indicate SEM derived from at least three independent experiments, (a) significance was calculated by 2-way analysis of variance (ANOVA) followed by Bonferroni test, and (b–e) significance was calculated by one-way analysis of variance ().

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