Locating the Site of Neuropathic Pain In Vivo Using MMP-12-Targeted Magnetic Nanoparticles

Figure 5

MMP-12-targeted probe is selectively cleaved by MMP-12 in vitro. (a) U87 glioma model MRI phantom showed lower intensity in the ROI (indicated by yellow circle) of (2) cells treated with probe only, compared to (3 and 4) cells treated with probe and MMP408, (5) untreated cells, and a (1) blank. (b) Microscopic observation of U87 cells stained with prussian blue, following incubation with the probe, shows iron-positive areas (scale bar = 100 μm).

(a)

(b)