Review Article

Efficacy and Safety of Ultrasound-Guided Radiofrequency Treatment for Chronic Pain in Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Table 3

Details of intervention, evaluation criterion, adverse effects, conclusion, and limitation of the nonrandomized studies.

First author (year)RF modeTarget locationUltrasound transducer parameterDiagnostic nerve blockEvaluation criterionReported adverse effectsConclusionLimitation

Djibilian Fucci et al. [26]PRFSciatic nerve3–6 MHzNoVASNoneUltrasound-guided PRF on sciatic nerve significantly relieved pain and may become a novel therapeutic approach for chronic knee painLack of control group; small sample size; short follow-up time; lack of evaluation for knee function

Ibrahim Aly et al. [27]PRFIntra-articular6–13 MHzYesNRS; WOMACEcchymosis at the site of injection (3/30)Intra-articular PRF was safe and beneficial for pain relief in patients with KOALack of control ; small sample size

Santana Pineda et al. [28]RFASL, SM, IM genicular nerve5–10 MHzNoVAS; WOMACNoneUltrasound-guided RFA of genicular nerve was a safe, effective, minimally invasive treatment for chronic pain and disability induced by KOALack of control group; small sample size

Erdem and Sir [29]PRFSL, SM, IM genicular nerve6–15 MHzNoVAS; WOMACNoneUltrasound-guided PRF targeting genicular nerves was a safe and minimally invasive procedure that significantly alleviated pain and disability in patients with severe KOALack of control; small sample size; short follow-up time

Ahmed and Arora [30]RFASM, SL, M, IM, IL, P genicular nerve; LRN6–13 MHzYESNRS; OKS; WOMAC; SF-36Hypoesthesia (2/8); numbness (1/8)Ultrasound-guided RFA targeting genicular nerves was safe and effective for significantly improving pain, disability and quality of life in patients with severe KOALack of control; small sample size

RF: radiofrequency; RFA: radiofrequency ablation; PRF: pulsed radiofrequency; SM: superior medial; SL: superior lateral; IM: inferior medial; IL: inferior lateral; M: middle; P: posterior; LRN: lateral retinacular nerve; VAS: visual analogue scale; NRS: numerical rating scale; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index; OKS: Oxford Knee Score; and SF-36: 36-Item Short-Form Health Survey.