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First author (year) | RF mode | Target location | Ultrasound transducer parameter | Diagnostic nerve block | Evaluation criterion | Reported adverse effects | Conclusion | Limitation |
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Djibilian Fucci et al. [26] | PRF | Sciatic nerve | 3–6 MHz | No | VAS | None | Ultrasound-guided PRF on sciatic nerve significantly relieved pain and may become a novel therapeutic approach for chronic knee pain | Lack of control group; small sample size; short follow-up time; lack of evaluation for knee function |
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Ibrahim Aly et al. [27] | PRF | Intra-articular | 6–13 MHz | Yes | NRS; WOMAC | Ecchymosis at the site of injection (3/30) | Intra-articular PRF was safe and beneficial for pain relief in patients with KOA | Lack of control ; small sample size |
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Santana Pineda et al. [28] | RFA | SL, SM, IM genicular nerve | 5–10 MHz | No | VAS; WOMAC | None | Ultrasound-guided RFA of genicular nerve was a safe, effective, minimally invasive treatment for chronic pain and disability induced by KOA | Lack of control group; small sample size |
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Erdem and Sir [29] | PRF | SL, SM, IM genicular nerve | 6–15 MHz | No | VAS; WOMAC | None | Ultrasound-guided PRF targeting genicular nerves was a safe and minimally invasive procedure that significantly alleviated pain and disability in patients with severe KOA | Lack of control; small sample size; short follow-up time |
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Ahmed and Arora [30] | RFA | SM, SL, M, IM, IL, P genicular nerve; LRN | 6–13 MHz | YES | NRS; OKS; WOMAC; SF-36 | Hypoesthesia (2/8); numbness (1/8) | Ultrasound-guided RFA targeting genicular nerves was safe and effective for significantly improving pain, disability and quality of life in patients with severe KOA | Lack of control; small sample size |
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