Perioperative Dexmedetomidine Fails to Improve Postoperative Analgesic Consumption and Postoperative Recovery in Patients Undergoing Lateral Thoracotomy for Thoracic Esophageal Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Table 4
Laboratory data.
Saline (n = 29)
Dexmedetomidine (n = 29)
value
Difference between mean/median
95% confidence interval
Blood cell count
Red blood cell
1012/L
Baseline
4.37 ± 0.50
4.38 ± 0.52
0.941
0.01 ± 0.134
[−0.258, 0.27]
POD2
3.70 ± 0.57
3.71 ± 0.54
0.946
0.01 ± 0.146
[−0.282, 0.302]
POD5
3.56 ± 0.57
3.58 ± 0.62
0.900
0.02 ± 0.156
[−0.293, 0.333]
Hemoglobin
g/L
Baseline
131.59 ± 11.56
130.21 ± 16.10
0.709
−1.380 ± 3.681
[−8.753, 5.993]
POD2
111.61 ± 14.62
109.12 ± 14.54
0.518
−2.490 ± 3.829
[−10.16, 5.18]
POD5
106.21 ± 15.09
105.28 ± 16.97
0.826
−0.93 ± 4.217
[−9.377, 7.517]
White blood cell
109/L
Baseline
5.69 ± 1.62
5.64 ± 1.51
0.911
−0.05 ± 0.411
[−8.378, 0.774]
POD2
11.03 ± 3.42
10.10 ± 3.44
0.314
−0.93 ± 0.901
[−2.734, 0.875]
POD5
7.63 ± 2.61
7.86 ± 3.67
0.792
0.23 ± 0.836
[−1.445, 1.905]
Basophils
109/L
Baseline
0.21 ± 0.93
0.05 ± 0.13
0.363
−0.16 ± 0.174
[−0.509, 0.189]
POD2
0.01 ± 0.007
0.008 ± 0.006
0.281
−0.002 ± 0.002
[−0.007, 0.002]
POD5
0.03 ± 0.56
0.04 ± 0.12
0.925
0.01 ± 0.106
[−0.203, 0.223]
Eosinophil
109/L
Baseline
0.85 ± 2.13
0.16 ± 0.12
0.090
−0.690 ± 0.396
[−1.484, 0.396]
POD2
0.34 ± 1.32
0.30 ± 1.31
0.908
−0.04 ± 0.345
[−0.732, 0.652]
POD5
0.21 ± 0.16
0.17 ± 0.13
0.301
−0.04 ± 0.038
[−0.117, 0.037]
Monocyte
109/L
Baseline
0.42 ± 0.19
0.37 ± 0.16
0.283
−0.05 ± 0.046
[−0.142, 0.042]
POD2
0.57 ± 0.23
0.56 ± 0.24
0.872
−0.01 ± 0.062
[−0.134, 0.114]
POD5
0.57 ± 0.27
0.55 ± 0.28
0.783
−0.02 ± 0.072
[−0.165, 0.125]
Platelet
109/L
Baseline
212.83 ± 68.14
196.72 ± 64.80
0.360
−16.11 ± 17.46
[−51.09, 18.87]
POD2
143.79 ± 40.62
153.64 ± 71.22
0.527
9.85 ± 15.23
[−20.65, 40.35]
POD5
199.59 ± 62.86
192.48 ± 73.08
0.639
−7.11 ± 17.9
[−42.97, 28.75]
Cytokines
CRP
μg/ml
Baseline
2.29 ± 1.27
2.23 ± 1.71
0.88
−0.06 ± 0.396
[−0.852, 0.7324]
End of surgery
1.47 ± 1.31
1.57 ± 1.63
0.80
0.1 ± 0.388
[−0.678, 0.878]
POD2
5.03 ± 0.59
5.21 ± 1.26
0.489
0.18 ± 0.258
[−0.338, 0.7]
POD5
4.80 ± 1.81
5.08 ± 1.51
0.525
0.28 ± 0.438
[−0.6, 1.157]
IL-6
pg/ml
Baseline
13.74 ± 8.63
11.19 ± 3.22
0.628
−2.55 ± 1.71
[−5.976, 0.877]
End of surgery
14.88 ± 6.36
17.27 ± 7.23
0.708
2.390 ± 1.788
[−1.192, 5.972]
POD2
15.91 ± 10.41
19.08 ± 8.11
0.59
3.17 ± .45
[−1.739, 8.079]
POD5
9.33 ± 4.18
14.22 ± 8.64
0.140
2.890 ± 1.782
[−0.68, 6.46]
IL-10
pg/ml
Baseline
15.79 ± 8.74
12.76 ± 7.88
0.674
−3.03 ± 2.185
[−7.408, 1.348]
End of surgery
23.70 ± 10.71
19.92 ± 11.02
0.191
−3.78 ± 2.854
[−9.496 to 1.936]
POD2
14.51 ± 6.94
19.39 ± 8.46
0.393
4.88 ± 2.032
[−10.95, 1.182]
POD5
14.92 ± 10.81
12.85 ± 8.12
0.928
−2.07 ± 2.511
[−3.998, 8.137]
Data are reported as the mean ± standard error as appropriate. POD: postoperative day.
