Central Sensitization in Neurological, Psychiatric, and Pain Disorders: A Multicenter Case-Controlled Study

Table 4

Relationship between the number of CSS-related diseases on CSI-B and CSI-A scores.

CSS-related diseases on CSI-B	n	%	CSI-A score				CSI-A score (more than 40 points)
			Mean^b	SE	value^a	Post hoc test^c	OR^d	95% CI	value	for trend
0 diseases	178	39.4	23.9	0.8	<0.001	0 vs. 1, 2, 3, 4–6	Ref.			<0.001
1 disease	171	37.8	29.5	0.8		1 vs. 2, 3, 4–6	2.70	1.15, 6.34	0.023
2 diseases	63	13.9	34.7	1.3		2 vs. 4–6	4.86	1.78, 13.25	0.002
3 diseases	25	5.5	36.3	2.1			20.09	5.16, 78.20	<0.001
4–6 diseases	15	3.3	43.2	2.7			38.59	6.97, 213.58	<0.001

CSS = central sensitization syndrome; CSI = Central Sensitization Inventory. ^aUsing a general linear model with ANCOVA; ^bafter adjustment for sex, age, BMI, smoking, alcohol, caffeine, BPI pain severity score, BPI pain interference score, and PHQ-9 score; ^cusing a Bonferroni test (); ^dusing a multivariable logistic model after adjusting for sex, age, BMI, smoking, alcohol, caffeine, BPI pain severity score, BPI pain interference score, and PHQ-9 score.