Research Article
Vitamin D Deficiency and Molecular Changes in Circulating MicroRNAs in Older Adults with Lower Back Pain
Table 2
Correlation between circulating miRNAs concentrations and biological parameters in patients with low back pain (LBP) (n = 110).
| Biological parameters | Whole cohort (qRT-PCR)a | Downregulated miRNAs | Upregulated miRNAs | miR-146a | miR-558 | miR-155 | miR-124a | R | P | R | P | R | P | R | P |
| Age | 0.78 | 0.12 | 0.67 | 0.19 | 0.59 | 0.23 | 0.74 | 0.13 | Gender | 0.48 | 0.11 | 0.36 | 0.14 | 0.29 | 0.17 | 0.43 | 0.16 | Adiposity (BMI/WHtR) | 0.46 | 0.001 | 0.26 | 0.001 | 0.49 | 0.003 | 0.76 | 0.002 | Muscle function | 0.26 | 0.01 | 0.18 | 0.01 | 0.28 | 0.01 | 0.25 | 0.02 | Malnutrition | 0.18 | 0.01 | 0.21 | 0.01 | 0.31 | 0.01 | 0.29 | 0.01 | PA score | 0.31 | 0.01 | 0.45 | 0.01 | 0.39 | 0.01 | 0.67 | 0.01 | Pain score | −0.48 | 0.001 | −0.78 | 0.001 | −0.58 | 0.001 | −0.96 | 0.001 | LBPscore (OSW score) | −0.86 | 0.001 | −0.128 | 0.001 | −0.38 | 0.001 | −0.49 | 0.001 | Inflammatory markers | | 0.001 | | 0.001 | | 0.001 | | 0.001 | TNF-α (pg/ml) | 0.45 | | 0.65 | | 0.71 | | 0.85 | | IL-6 (pg/ml) | 0.39 | | 0.38 | | 0.65 | | 0.235 | | CRP (mg/L) | 0.75 | | 0.86 | | 0.48 | | 0.345 | | Bone metabolism | | 0.001 | | 0.001 | | 0.001 | | 0.001 | s-Ca (mmol/L) | −0.48 | | −0.86 | | −0.48 | | −0.87 | | s-BAP (U/L) | −0.26 | | −0.56 | | −0.75 | | −0.59 | | s-OC (ng/mL) | −0.36 | | −0.37 | | −0.18 | | −0.48 | | S-NTX (pg/mL) | −0.58 | | −0.48 | | −0.56 | | −0.56 | | Vitamin D status | 0.65 | 0.001 | 0.38 | 0.001 | 0.89 | 0.002 | 0.78 | 0.001 |
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aData are R (spearman). Abbreviations: BMI: body mass index; WHtR: waist-to-height ratio; PA: physical activity; TNF-α: tumor necrosis factor-alpha; IL-6: interleukin-6; CRP: C-reactive protein; s-Ca: serum calcium; s-BAP: serum bone-specific alkaline phosphatase; s-OC: serum osteocalcin; S-NTX: serum C-terminal cross-linked telopeptide of type I collagen; LBP: low back pain; OSW: Oswestry Low Back Pain Disability Questionnaire, miR: microRNA.
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