Vitamin D Deficiency and Molecular Changes in Circulating MicroRNAs in Older Adults with Lower Back Pain

Table 2

Correlation between circulating miRNAs concentrations and biological parameters in patients with low back pain (LBP) (n = 110).

Biological parameters	Whole cohort (qRT-PCR)^a
	Downregulated miRNAs				Upregulated miRNAs
	miR-146a		miR-558		miR-155		miR-124a
	R	P	R	P	R	P	R	P
Age	0.78	0.12	0.67	0.19	0.59	0.23	0.74	0.13
Gender	0.48	0.11	0.36	0.14	0.29	0.17	0.43	0.16
Adiposity (BMI/WHtR)	0.46	0.001	0.26	0.001	0.49	0.003	0.76	0.002
Muscle function	0.26	0.01	0.18	0.01	0.28	0.01	0.25	0.02
Malnutrition	0.18	0.01	0.21	0.01	0.31	0.01	0.29	0.01
PA score	0.31	0.01	0.45	0.01	0.39	0.01	0.67	0.01
Pain score	−0.48	0.001	−0.78	0.001	−0.58	0.001	−0.96	0.001
LBPscore (OSW score)	−0.86	0.001	−0.128	0.001	−0.38	0.001	−0.49	0.001
Inflammatory markers		0.001		0.001		0.001		0.001
TNF-α (pg/ml)	0.45		0.65		0.71		0.85
IL-6 (pg/ml)	0.39		0.38		0.65		0.235
CRP (mg/L)	0.75		0.86		0.48		0.345
Bone metabolism		0.001		0.001		0.001		0.001
s-Ca (mmol/L)	−0.48		−0.86		−0.48		−0.87
s-BAP (U/L)	−0.26		−0.56		−0.75		−0.59
s-OC (ng/mL)	−0.36		−0.37		−0.18		−0.48
S-NTX (pg/mL)	−0.58		−0.48		−0.56		−0.56
Vitamin D status	0.65	0.001	0.38	0.001	0.89	0.002	0.78	0.001

^aData are R (spearman). Abbreviations: BMI: body mass index; WHtR: waist-to-height ratio; PA: physical activity; TNF-α: tumor necrosis factor-alpha; IL-6: interleukin-6; CRP: C-reactive protein; s-Ca: serum calcium; s-BAP: serum bone-specific alkaline phosphatase; s-OC: serum osteocalcin; S-NTX: serum C-terminal cross-linked telopeptide of type I collagen; LBP: low back pain; OSW: Oswestry Low Back Pain Disability Questionnaire, miR: microRNA.