Head and neck regions could be often affected by inflammatory, neoplastic, immune, infectious, or degenerative diseases. Dentists, otorhinolaryngologists, maxillofacial surgeons, physicians, immunologists, endocrinologists, dermatologists, ophthalmologists, and neurologists are involved in the treatment of these conditions.

Sometimes, the diagnosis of head and neck pain is difficult to perform. In fact, pain is a subjective feeling based on symptoms referred by patients and on the clinical evaluation of several characteristics, such as the area, the time trend, the irradiation, the possible regression after a specific therapy, and the psychological effects.

Head and neck pain can be caused by several factors like vascular, neurological, muscular, articular, and psychogenic ones. In order to better understand and distinguish the pain source, several diagnostic techniques have been developed during the time, permitting recognizing the etiology and the type of pain. Moreover, the therapies can be based on the use of traditional drugs or new molecules; otherwise, they can be less invasive, for example, laser therapy or acupuncture avoiding the systemic toxicity of drugs and exploiting other mechanisms, such as the alteration of the nervous action potential, the stimulation of the production of endogenous morfino-mimetic substances, or restoring of the body energy balance.

The editors are soliciting manuscripts that focus on interventions designed to improve quality of life among people with pain arising from oral and maxillofacial diseases. However, we will consider all high quality original research articles, clinical studies, and review articles which focused on the topic of pain in oral and maxillofacial diseases. 

Potential topics include, but are not limited to:

• Head and neck pathology
• Oral and maxillofacial surgery
• Oral medicine
• Headaches
• Trigeminal pains
• Muscle aches
• Lasers
• Acupuncture
• Drugs
• Temporomandibular disorders
• Brain imaging
• Quantitative Sensory Testing (QST)
• CNS-based electrodiagnosis