Migraine is a common health complaint and is a major cause of disability across all age groups. It is typically unilateral and frequently accompanied by a throbbing or pulsating sensation and other associated symptoms, including nausea, vomiting, phonophobia, and photophobia. It is believed that neuroinflammation, dysfunction of the descending pain-modulating network, altered trigeminal and autonomic system function, and other mechanisms may contribute to the disorder.

Although efforts have been paid to the investigation of this disease, clear understanding of its etiology remains elusive. There is still a lack of effective diagnosis and treatment methods for migraine.

This special issue aims to cover migraine related basic and clinical studies. Authors are encouraged to submit review as well original research articles that will improve our awareness of novel treatment options. We are particularly interested in articles providing new pathophysiological insights and diagnostic methods for migraine. We also welcome systematic reviews which describe the current state of the art.

Potential topics include but are not limited to the following:

• Novel insights into the genetic, cellular, and molecular basis of migraine
• Epidemiology, risk factors, and clinical performances of migraine
• Development of new diagnostic tools of migraine
• New drugs and therapeutic methods for migraine