Surgical Incision Induces Anxiety-Like Behavior and Amygdala Sensitization: Effects of Morphine and Gabapentin

Figure 4

Effect of analgesics on incision-evoked pain hypersensitivity and anxiety-like behavior. Effect of morphine (2.5 mg/kg and 10 mg/kg), gabapentin (30 mg/kg and 300 mg/kg), or the combined morphine (2.5 mg/kg) and gabapentin(30 mg/kg) on the PWT and time spent on open-arm following hind-paw incision. (a) and (c) show the time-course changes in PWT and time spent in open arm in response to surgical and pharmacological treatments. The comparison of PWT and time spent in open-arm between the combined morphine (2.5 mg/kg) and gabapentin(30 mg/kg) and morphine (2.5 mg/kg) or gabapentin (10 mg/kg) at 1 hour after operation are displayed in (b) and (d). G indicates gabapentin; M indicates morphine; G $+\hspace{0.17em}$M indicates the combined treatment of morphine (2.5 mg/kg) and gabapentin (30 mg/kg). $n=7$ for each group.

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