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Pain Research and Treatment
Volume 2012, Article ID 104782, 5 pages
Clinical Study

Effect of Diclofenac with B Vitamins on the Treatment of Acute Pain Originated by Lower-Limb Fracture and Surgery

1Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, 42090 Pachuca, HGO, Mexico
2Research and Traumatology Departments, Hospital del Niño DIF, 42090 Pachuca, HGO, Mexico
3Hospital General de los Servicios de Salud del Estado de Hidalgo, 42090 Pachuca, HGO, Mexico
4SubDirección de Investigación de los Servicio de Salud de Hidalgo, 42030 Pachuca, HGO, Mexico
5Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, IPN, 11340, DF, Mexico

Received 11 August 2011; Revised 22 September 2011; Accepted 27 September 2011

Academic Editor: María Asunción Romero Molina

Copyright © 2012 Héctor A. Ponce-Monter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This was a single-center, prospective, randomized, and double-blinded clinical trial. Patients with lower-limb closed fractures rated their pain on a 10 cm visual analog scale (VAS). Patients were then randomized to receive diclofenac or diclofenac plus B vitamins (thiamine, pyridoxine, and cyanocobalamin) intramuscularly twice daily. Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours presurgery and twenty-four hours postsurgical. One hundred twenty-two patients completed the study. The subjects' assessments of limb pain on the VAS showed a significant reduction from baseline values regardless of the treatment group. Diclofenac plus B vitamins combination was more effective to reduce the pain than diclofenac alone. The results showed that the addition of B vitamins to diclofenac increased its analgesic effect. The novelty of this paper consists in that diclofenac and diclofenac plus B vitamins were useful for treatment of acute pain originated by lower-limb fracture and surgery.