Pain Research and Treatment / 2012 / Article / Tab 8

Clinical Study

Validation of the Self-Assessment of Treatment Questionnaire among Patients with Postherpetic Neuralgia

Table 8

Known-groups validity: ANOVA models of SAT scores by global assessment levels at week 12 (pooled dataset; )1.

SAT at Week 12
n(1) Pain relief(2) Activity level(3) Quality of life(4) Undergo treatment again(5) Compared to previous treatment3-Item SAT treatment effect subscale2-Item SAT treatment satisfaction subscale

PGIC, LS mean (SE)
 Very much improved1031.9 (0.0)1.4 (0.1)1.7 (0.1)1.7 (0.1)1.7 (0.1)5.0 (0.1)3.5 (0.2)
 Much improved1151.4 (0.0)0.8 (0.1)1.0 (0.0)1.6 (0.1)1.1 (0.1)3.3 (0.1)2.7 (0.1)
 Slightly improved1590.8 (0.0)0.3 (0.0)0.5 (0.0)1.1 (0.1)0.5 (0.1)1.6 (0.1)1.6 (0.1)
 No change2750.0 (0.0)0.0 (0.0)0.0 (0.0)0.6 (0.1)0.0 (0.1)−0.1 (0.1)0.6 (0.1)
 Slightly worse31−0.7 (0.1)−0.3 (0.1)−0.1 (0.1)0.0 (0.2)−0.2 (0.2)−1.1 (0.2)−0.2 (0.3)
 Much worse214−1.2 (0.1)−0.9 (0.2)−0.9 (0.1)−0.9 (0.3)−1.1 (0.2)−3.0 (0.3)−2.0 (0.4)
-value<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001

CGIC3, LS mean (SE)
 Very much improved631.9 (0.1)1.4 (0.1)1.7 (0.1)1.7 (0.1)1.7 (0.1)5.0 (0.2)3.5 (0.2)
 Much improved561.4 (0.1)0.7 (0.1)1.0 (0.1)1.3 (0.1)1.1 (0.1)3.0 (0.2)2.4 (0.2)
 Slightly improved780.7 (0.1)0.3 (0.1)0.5 (0.1)0.9 (0.1)0.4 (0.1)1.5 (0.2)1.3 (0.2)
 No change140−0.1 (0.0)−0.1 (0.1)−0.1 (0.0)0.3 (0.1)−0.2 (0.1)−0.3 (0.1)0.1 (0.1)
 Slightly worse10−0.1 (0.2)0.1 (0.2)0.2 (0.2)−0.2 (0.3)−0.1 (0.3)0.2 (0.4)−0.3 (0.5)
 Much worse22−1.5 (0.4)−0.5 (0.5)−0.5 (0.4)−1.5 (0.7)−0.5 (0.7)−2.5 (1.0)−2.0 (1.1)
-value<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001

ANOVA: analysis of variance; CGIC: Clinician Global Impression of Change; LS: least-squares; PGIC: Patient Global Impression of Change; SAT: Self-Assessment of Treatment; SE: standard error.
nown-groups validity was assessed using ANOVA to evaluate whether SAT items and subscale scores discriminated between patient groups based on different amounts of patient- and clinician-reported change at Week 12. Pooled dataset included data from two clinical trials, Studies C116 ( ) and C117 ( ).
GIC and CGIC responses of “Very much worse” and “Much worse” were combined due to small sample sizes.
tudy C117 only.

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