Polymorphism of μ-Opioid Receptor Gene (OPRM1:c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting

Table 2

The association between the incidences of IVPCA morphine-induced side effects and genotype.

		Total	Genotype			P value
			A/A (𝑛=56)	A/G (𝑛=57)	G/G (𝑛=16)
Nausea	Yes	81 (62.8%)	34 (60.7%)	37 (64.9%)	10 (62.5%)	0.935
	No	48 (37.2%)	22 (39.3%)	20 (35.1%)	6 (37.5%)
Vomiting	Yes	58 (45.0%)	24 (42.9%)	26 (45.6%)	8 (50.0%)	0.882
	No	71 (55.0%)	32 (57.1%)	31 (54.4%)	8 (50.0%)
Nausea or Vomiting	Yes	82 (63.6%)	35 (62.5%)	37 (64.9%)	10 (62.5%)	0.967
	No	47 (36.4%)	21 (37.5%)	20 (35.1%)	6 (37.5%)
Itching	Yes	14 (10.9%)	7 (12.5%)	6 (10.5%)	1 (6.3%)	0.857
	No	115 (89.1%)	49 (87.5%)	51 (89.5%)	15 (93.8%)
Dizziness	Yes	61 (47.3%)	25 (44.6%)	26 (45.6%)	10 (62.5%)	0.469
	No	68 (52.7%)	31 (55.4%)	31 (54.4%)	6 (37.5%)
Lethargy	Yes	12 (9.3%)	7 (12.5%)	4 (7.0%)	1 (6.3%)	0.579
	No	117 (90.7%)	49 (87.5%)	53 (93.0%)	15 (93.8%)