Effect of Pregabalin on Cardiovascular Responses to Exercise and Postexercise Pain and Fatigue in Fibromyalgia: A Randomized, Double-Blind, Crossover Pilot Study

Table 3

Exercise task variables (mean ± SE) during pregabalin and placebo conditions in patients and healthy controls.

	Controls	All patients ()		All patients, value
	()	Pregabalin	Placebo	Preg versus Con	Plac versus Con	Preg versus Plac
WR (kcal/hr)	318 ± 11.6	301 ± 14.9	286 ± 15.4	0.387	0.109	0.114
RPE	3.4 ± 0.3	4.1 ± 0.4	4.9 ± 0.4	0.172	0.011	0.049
HR (bpm)	127 ± 2.1	115 ± 2.5	122 ± 3.6	0.001	0.276	0.024
HR (% PMHR)	71 ± 0.7	65 ± 1.2	69 ± 1.8	<0.001	0.404	0.029
SBP (mm Hg)	142 ± 3.7	142 ± 3.8	153 ± 3.7	0.926	0.031	0.017
DBP (mm Hg)	86 ± 2.3	88 ± 2.6	91 ± 2.2	0.676	0.086	0.136
HR/WR	41 ± 1.5	40 ± 1.8	45 ± 3.2	0.606	0.219	0.034
SBP/WR	46 ± 2.3	49 ± 2.6	57 ± 3.4	0.345	0.013	0.002
DBP/WR	28 ± 1.2	30 ± 1.8	34 ± 2.3	0.229	0.020	0.037

WR: work-rate; RPE: rating of perceived exertion; HR: heart rate; PMHR: age-predicted maximal heart rate; SBP: systolic blood pressure; DBP: diastolic blood pressure; HR/WR, SBP/WR, and DBP/WR: values expressed relative to exercise work-rate (kcal/hr) multiplied by 100; Preg: pregabalin; Plac: placebo.