Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model

Figure 2

Antinociceptive effects of acute treatment with RSV + RO or PGB on latency time (s) in response to thermal stimulation in the fibromyalgia model. PGB was used as a positive control drug. Thermal hyperalgesia was assessed in the hot plate test, on the 4th day after onset of reserpine administration (0.25 mg/kg, s.c., once a day for three days), 30 min after treatment administration. Data are presented as mean ± SEM. compared to control (SAL-SAL), compared do RES-SAL group, compared to RES-RSV-RO, and compared to RES-RSV-RO. Statistical analysis was performed by one-way ANOVA followed by Bonferroni’s post hoc test. to 11 mice/group.