Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model

Figure 4

Effects of chronic treatment with RSV, RSV + RO, or PGB on reserpine-induced nociception in the fibromyalgia model in mice. On the 4th day, mice receiving reserpine (0.25 mg/kg, s.c., once a day for 3 days) and treated orally with RSV (100 mg/kg once a day for 4 days), RSV + RO (10 mg/kg once a day for 4 days), RO (10 mL/kg once a day for 4 days), or PGB (30 mg/kg once a day for 4 days) were tested through Von Frey stimulation for mechanical allodynia (a) and in the open field test for thermal hyperalgesia (b). Data are presented as mean ± SEM. compared to control (SAL-SAL), , , and compared to RES-SAL group, and compared to RES-RSV-RO. Statistical analysis was performed by one-way ANOVA followed by Bonferroni’s post hoc test. (a) to 13 mice/group; (b) to 8 mice/group. compared to control (SAL-SAL).

(a)

(b)