Pain Research and Treatment

Primary Afferent Nociceptor as a Target for the Relief of Pain


Publishing date
12 Feb 2012
Status
Published
Submission deadline
12 Aug 2011

1Department of Physiology and Biophysics, Institute of Biology, State University of Campinas, São Paulo, Brazil

2Piracicaba Dental School, State University of Campinas, Campinas, São Paulo, Brazil

3Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z4


Primary Afferent Nociceptor as a Target for the Relief of Pain

Description

The sensitization of primary afferent nociceptors is essential to the development of inflammatory pain as well as to the development of most neuropathic pain. Recent advances in biology and medicine have introduced new technologies to study neuronal mechanisms underlying primary afferent nociceptors sensitization. Knowing and understanding these mechanisms have led to the development of animal models and revealed novel targets to the development of drugs that selectively act on primary afferent nociceptors and new conceptional idea about pain relief.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular mechanisms underlying primary afferent nociceptors sensitization involved in acute or persistent hyperalgesia. We are particularly interested in articles describing the new insights into inflammatory or neuropathic hyperalgesia using animal models, advances in the control of nociception or hyperalgesia by targeting primary afferent nociceptors, mechanism of action of drugs that act on primary afferent neurons, new strategies to control inflammatory or neuropathic hyperalgesia using neuroprotections, small molecules, ODN antisenses or SiRNA, and stem cells, and drugs' delivery to primary afferent neurons. Potential topics include, but are not limited to:

  • Recent development in the control of inflammatory or neuropathic hyperalgesia by targeting primary afferent neurons
  • Identification of new targets in primary afferent neurons to control pain
  • Signaling pathways involved in primary afferent nociceptors sensitization
  • New animals models of inflammatory or neuropathic pain
  • Mechanism of action of drugs that act on primary afferent neurons
  • Role of dorsal root ganglia cells in inflammatory or neuropathic hyperalgesia
  • Interactions between nonneuronal cells of the peripheral tissue (e.g., keratocytes, polymorphonuclear cells) and nociceptors

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/prt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 348043
  • - Editorial

Primary Afferent Nociceptor as a Target for the Relief of Pain

Carlos A. Parada | Claudia H. Tambeli | ... | Brian E. Cairns
  • Special Issue
  • - Volume 2012
  • - Article ID 545386
  • - Review Article

Peripheral Galanin Receptor 2 as a Target for the Modulation of Pain

Richard P. Hulse | Lucy F. Donaldson | David Wynick
  • Special Issue
  • - Volume 2012
  • - Article ID 414697
  • - Research Article

Glutaminase Immunoreactivity and Enzyme Activity Is Increased in the Rat Dorsal Root Ganglion Following Peripheral Inflammation

Kenneth E. Miller | John C. Balbás | ... | Ruben Schechter
  • Special Issue
  • - Volume 2012
  • - Article ID 817347
  • - Research Article

ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections

Mamta Gautam | Christopher J. Benson | ... | Kathleen A. Sluka
  • Special Issue
  • - Volume 2012
  • - Article ID 915706
  • - Research Article

Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin

You-Hong Jin | Motohide Takemura | ... | Norifumi Yonehara
  • Special Issue
  • - Volume 2012
  • - Article ID 693912
  • - Research Article

Aging Independently of the Hormonal Status Changes Pain Responses in Young Postmenopausal Women

Yannick Tousignant-Laflamme | Serge Marchand
  • Special Issue
  • - Volume 2012
  • - Article ID 960780
  • - Review Article

Estrogen and Visceral Nociception at the Level of Primary Sensory Neurons

Victor Chaban

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