Pain Research and Treatment

Analgesic Drugs Combinations in the Treatment of Different Types of Pain


Publishing date
01 Jun 2012
Status
Published
Submission deadline
01 Dec 2011

Lead Editor

1Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo, Mexico

2Department of Physiopathology and Treatment of Pain, Fundació Institut Municipal d'Investigació Mèdica-Parc de Salut Mar, Barcelona, Spain

3Multidisciplinary Pain Centre, Aichi Medical University, School of Medicine, Japan

4Department of Reconstructive Surgery and Osteo-articular Infections, Orthopaedic Research Institute Galeazzi, Milan, Italy


Analgesic Drugs Combinations in the Treatment of Different Types of Pain

Description

Pain relief can be achieved by a diversity of methods, with drug use being the basis of analgesic treatment. Clinical use of combinations of analgesic drugs has augmented considerably in the last few years. The purpose of combining two or more drugs with different mechanisms of action is to achieve a synergistic interaction, yielding a sufficient analgesic effect with lower doses and, therefore, reduce the intensity and incidence of untoward effects. At present, many diverse classes of drugs serve as an efficient complement to nonsteroidal anti-inflammatory drugs (NSAIDs) or opioids in the management of pain. Opioids have frequently been used in combination with NSAIDs for the clinical management of both acute and chronic pain. At the end, the use of this combination limits the doses of medication that a patient can receive. However, not all the opioid-NSAID combinations are clinically successful in all cases. For example, the association of weak opioids, such as dextropropoxyphene, to acetaminophen does not significantly increase pain relief with respect to acetaminophen alone. Likewise, the combination of codeine with paracetamol results in additional pain relief but may be accompanied by an increase in drowsiness and dizziness. Therefore, several other combinations of analgesic agents must be evaluated experimentally or clinically to gain insight into their potential clinical use.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to obtain useful evidence about the use of drug combination in the treatment of pain. We are particularly interested in articles describing novelty models for experimental or clinical characterization of drug combinations in the management of painful states, new insights into action mechanism of the drug interactions, and evaluation of adverse reactions. Potential topics include, but are not limited to:

  • Development of drug interaction mathematic models
  • Interaction between opioids or nonopioids with nonsteroidal anti-inflammatory drugs
  • Drug interaction models in animals
  • Drug combination in painful states in human
  • Pharmacodinamic and/or pharmacokinetics studies about drug combination in animals or patients with pain
  • Adverse reactions due to drug combination in patients with pain
  • Drugs-herbal products combinations in animals or patients with pain

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/prt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 612519
  • - Editorial

Analgesic Drugs Combinations in the Treatment of Different Types of Pain

Mario I. Ortiz | María Asunción Romero Molina | ... | Carlo Luca Romanò
  • Special Issue
  • - Volume 2012
  • - Article ID 154781
  • - Review Article

Antineuropathic and Antinociceptive Drugs Combination in Patients with Chronic Low Back Pain: A Systematic Review

Carlo Luca Romanò | Delia Romanò | Marco Lacerenza
  • Special Issue
  • - Volume 2012
  • - Article ID 150842
  • - Research Article

Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice

Maral Tajerian | Magali Millecamps | Laura S. Stone
  • Special Issue
  • - Volume 2012
  • - Article ID 295926
  • - Clinical Study

Efficacy and Tolerability of Fixed-Dose Combination of Dexketoprofen and Dicyclomine Injection in Acute Renal Colic

A. Porwal | A. D. Mahajan | ... | S. Sengupta
  • Special Issue
  • - Volume 2012
  • - Article ID 145965
  • - Review Article

Effects of Combined Opioids on Pain and Mood in Mammals

Richard H. Rech | David J. Mokler | Shannon L. Briggs
  • Special Issue
  • - Volume 2012
  • - Article ID 296710
  • - Research Article

Efficacy and Safety of Duloxetine in Patients with Chronic Low Back Pain Who Used versus Did Not Use Concomitant Nonsteroidal Anti-Inflammatory Drugs or Acetaminophen: A Post Hoc Pooled Analysis of 2 Randomized, Placebo-Controlled Trials

Vladimir Skljarevski | Peng Liu | ... | James M. Martinez
  • Special Issue
  • - Volume 2012
  • - Article ID 840486
  • - Review Article

Combination Drug Therapy for Pain following Chronic Spinal Cord Injury

Aldric Hama | Jacqueline Sagen
  • Special Issue
  • - Volume 2012
  • - Article ID 104782
  • - Clinical Study

Effect of Diclofenac with B Vitamins on the Treatment of Acute Pain Originated by Lower-Limb Fracture and Surgery

Héctor A. Ponce-Monter | Mario I. Ortiz | ... | Eduardo Fernández-Martínez