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Plastic Surgery International
Volume 2013 (2013), Article ID 146764, 7 pages
Review Article

Complements and the Wound Healing Cascade: An Updated Review

Division of Plastic and Reconstructive Surgery, Department of Surgery, McGill University, Montreal, QC, Canada H3A 2B4

Received 12 March 2013; Accepted 30 June 2013

Academic Editor: Georg M. Huemer

Copyright © 2013 Hani Sinno and Satya Prakash. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Wound healing is a complex pathway of regulated reactions and cellular infiltrates. The mechanisms at play have been thoroughly studied but there is much still to learn. The health care system in the USA alone spends on average 9 billion dollars annually on treating of wounds. To help reduce patient morbidity and mortality related to abnormal or prolonged skin healing, an updated review and understanding of wound healing is essential. Recent works have helped shape the multistep process in wound healing and introduced various growth factors that can augment this process. The complement cascade has been shown to have a role in inflammation and has only recently been shown to augment wound healing. In this review, we have outlined the biology of wound healing and discussed the use of growth factors and the role of complements in this intricate pathway.