Complements C3 and C5 Individually and in Combination Increase Early Wound Strength in a Rat Model of Experimental Wound Healing
Figure 1
Maximal wound breaking strength of treated wounds as compared to control wounds at Day 3. In the horizontal axis, “collagen” represents the tensometry of the collagen treated wounds in the sham rats. The C3 (100 nM) [2], C5 (10 nM) [3], and C5 (100 nM) represent the tensometry of the complement (concentration) in collagen solution on experimental wounds. The C3C5 (100 nM) represents the combination of complements C3 and C5 in collagen formulation at concentrations of 100 nM on experimental wounds. Treatment of wounds with C3 (100 nM), and C5 (10 nM), C5 (100 nM) has been shown previously to increase MWBS as compared to sham wounds. The increase of MWBS attained with the application of C3C5 in combination does not seem to significantly differ than with the administration of C3 and C5 alone. A significant increase of 88% in maximal wound breaking strength can be seen with topical formulation of C3C5 at concentrations of 100 nM at Day 3. *.
