Table of Contents
Plastic Surgery International
Volume 2013, Article ID 641570, 10 pages
Research Article

Implementing the Brazilian Database on Orofacial Clefts

1Medical Genetics Sector, State University of Alagoas (UNCISAL), Brazil
2Clinical Genetics Service, Federal University of Alagoas (UFAL), Brazil
3Medical Genetics Sector, Hospital Infantil Albert Sabin (HIAS), Brazil
4Medical Genetics Sector, Assistance Center for Cleft Lip and Palate (CAIF), Brazil
5Medical Genetics Sector, Facial Deformity Care Center (CADEFI), Brazil
6Medical Genetics Service, Hospital de Clínicas de Porto Alegre (HCPA), Brazil
7Molecular Biology Department, Medicine School of São José do Rio Preto (FAMERP/FUNFARME), Brazil
8Department of Medical Genetics, Faculty of Medical Sciences, University of Campinas, 13083-887, Brazil
9Dundee University Dental School, UK

Received 28 July 2012; Accepted 7 February 2013

Academic Editor: Renato Da Silva Freitas

Copyright © 2013 Isabella Lopes Monlleó et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. High-quality clinical and genetic descriptions are crucial to improve knowledge of orofacial clefts and support specific healthcare polices. The objective of this study is to discuss the potential and perspectives of the Brazilian Database on Orofacial Clefts. Methods. From 2008 to 2010, clinical and familial information on 370 subjects was collected by geneticists in eight different services. Data was centrally processed using an international system for case classification and coding. Results. Cleft lip with cleft palate amounted to 198 (53.5%), cleft palate to 99 (26.8%), and cleft lip to 73 (19.7%) cases. Parental consanguinity was present in 5.7% and familial history of cleft was present in 26.3% subjects. Rate of associated major plus minor defects was 48% and syndromic cases amounted to 25% of the samples. Conclusions. Overall results corroborate the literature. Adopted tools are user friendly and could be incorporated into routine patient care. The BDOC exemplifies a network for clinical and genetic research. The data may be useful to develop and improve personalized treatment, family planning, and healthcare policies. This experience should be of interest for geneticists, laboratory-based researchers, and clinicians entrusted with OC worldwide.