Therapeutic Options of Chondrodermatitis Nodularis Helicis

Juul Nielsen, Lea; Holkmann Olsen, Caroline; Lock-Andersen, Jørgen

doi:https://doi.org/10.1155/2016/4340168

Plastic Surgery International

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Review Article | Open Access

Volume 2016 | Article ID 4340168 | https://doi.org/10.1155/2016/4340168

Therapeutic Options of Chondrodermatitis Nodularis Helicis

Lea Juul Nielsen,¹Caroline Holkmann Olsen,²and Jørgen Lock-Andersen¹

Academic Editor: Nicolo Scuderi

Received27 Oct 2015

Accepted03 Jan 2016

Published27 Jan 2016

Abstract

Chondrodermatitis Nodularis Helicis is a benign inflammatory process affecting the skin and cartilage of the ear. It typically presents as a painful nodule surrounded by an area of erythema and often prevents the patient from sleeping on the affected side. Many treatments have been described in the literature, but the condition is prone to recurrence. A literature search was performed in order to identify the best possible treatment. Fifty-eight articles were included, describing and investigating nonsurgical as well as surgical treatment modalities. Large prospective, controlled, and randomised long-term studies are lacking, but based on the available literature, we recommend starting with a conservative approach using decompression devices. Simple surgical procedures should only be used if conservative measures fail.

1. Introduction

Chondrodermatitis Nodularis Helicis (CNH) is an inflammatory process affecting the skin and cartilage of the ear. Typically, it presents as a painful nodule of the helix and to a lesser extent the antihelix of the ear. Therefore, some have suggested changing the name to chondrodermatitis nodularis auricularis, as lesions are seen both on the helix and on the antihelix [1] and have even been reported on the posterior ear and in the external auditory canal [2, 3].

The condition was first described by the dermatologist Winkler in 1915 [4], who reported eight cases and soon afterwards by Foerster, who reported a further four cases [5]. Foerster later defined the condition in 1925 [6], with an additional eight cases, describing the clinical and microscopic features and the treatment of the condition.

The anatomy of the ear is unique, because the skin of the anterior and posterior surface is adherent to the perichondrium and is devoid of subcutaneous fat. The blood supply is provided by a rich subdermal plexus of vessels lying in the fascial layer between the skin and the perichondrium. The arterial supply to the auricle is derived from branches of the superficial temporal artery and the postauricular artery, so that the lateral surface of the ear has a dual arterial supply [7].

2. Method and Material

This paper is presented as a literature review. A PubMed search was performed on the 18th of December 2015 using the search term “chondrodermatitis”, identifying 134 articles. Primarily, abstracts of articles from 1996 onwards were reviewed leading to a full article review according to relevance. Articles with special focus on treatment modalities were included. Reference lists of selected articles were reviewed for other relevant articles.

3. Results

Fifty-eight articles were included: 13 prospective studies [8–20], 16 retrospective studies [1, 21–35], 4 case series [36–39], 13 case reports [2, 3, 40–50], 8 descriptions of treatment methods [7, 51–57], and 4 reviews [58–61].

In general, the literature on CNH is of fairly low quality, as it includes many case reports and retrospective studies. The 13 prospective studies are neither randomised, blinded nor controlled, although one histopathological study, investigating nerve hyperplasia, did include other tumours of the ear as controls. Most of the prospective studies involve only small cohorts of patients ranging from 5 to 99. Many articles lack information on anamnesis, symptoms, clinical signs, or length of follow-up as well as a clear definition of outcome (i.e., is a successful outcome reduced pain, absence of pain, reduction in size of nodule, or complete resolution of the nodule?). The follow-up period is generally short, ranging from 2 to 12 months, although a few studies report on follow-up intervals of up to 41–96 months. Another weakness in most of the studies is the presence of confounding treatment modalities: many patients had previously tried other treatments, some were subjected to more than one treatment, and many were advised to decompress the lesion in conjunction with the investigated treatment.

3.1. Clinical Presentation

CNH typically presents with an oval shaped nodule with elevated edges and a central crust or depression, usually 4–6 mm in diameter and frequently surrounded by an area of erythema. The nodule is usually firm to touch and bound to the underlying cartilage. It is characterised by exquisite tenderness, which often prevents the patient from sleeping on the affected side. Typically, the nodule is located on the outer ear (for men often on the helix and for women often on the antihelix) but locations on the posterior ear [2] and in the external auditory canal [3] have also been reported (see Figure 1). The lesions are typically located on the ear of the preferred sleeping-side, the right side being predominant, and are typically unilateral, although bilateral lesions have also been reported [8, 40–42]. Nocturnal pain is by far the most common symptom, with only few complaints of pain during the day, except when touched. Other features associated with the nodules include crusting, bleeding, and exudate, which can make it difficult to exclude skin malignancy.

Figure 1

Pre- and postoperative pictures of a patient with CNH. 79-year-old woman with recurrence of CNH on the left antihelix. Two years prior to referral the patient was treated surgically (unknown method) for CNH in the same location. Recurrence occurred 3 months before referral and was initially treated with topical sodium fusidate with no effect. Treated with excision of skin and underlying cartilage and coverage of the defect with full thickness skin graft, all symptoms resolved and an acceptable cosmetic outcome was obtained at 3-month follow-up.

3.2. Gender and Age Distribution

Historically, the literature describes a striking preponderance of males (10 : 1). In this review, 27 studies reported on the gender distribution, including a total of 628 males and 452 females, resulting in a male to female ratio of 1 : 0.7. As the exact cause of CNH is unknown, any discussion on the reasons for the gender difference is speculative.

CNH most commonly presents in patients over 40, although there have been isolated reports of children also affected [43–45]. Excluding all case reports and including only studies where a mean age is reported, 21 studies reported a mean age from 43 to 76 years.

Studies on incidence and prevalence were not identified, but anecdotally, our pathology department reports that the incidence is common.

3.3. Pathogenesis

The pathomechanism of CNH has not yet been fully uncovered. The striking and repeated observation that CNH is usually unilateral and usually affects the ear of the preferred sleeping-side suggests that pressure damage, predominantly from the weight of the head during sleep, is the most important aetiological factor. CNH arising from pressure due to hearing aids and other headgear has also been described [9, 21, 42, 44, 46]. Other aetiological factors such as trauma from cold (frostbite) and actinic damage have also been suggested [9, 21–23, 40, 42–47, 58].

It is possible that anatomical features of the individual (e.g., a grossly protruding helix or antihelix) predispose to the condition, but in most cases, the cartilage does not have to be grossly abnormal to initiate the disease. As the ear-shape does not change much during adult life, other factors must cause development of the disease in an otherwise unaffected ear. This could be due to distortion or calcification due to injury or simply because the cartilage becomes less flexible with increasing age and hence more vulnerable to pressure damage. It is also possible that the difference in site distribution between men and women is explained by the presence of a more protuberant helix in men and a more protuberant antihelix in women [24].

It has been suggested that pressure or repeated trauma may lead to ischemia of the cartilage and the auricular perichondrium. This arises because of the lack of protection of a thick subcutaneous tissue and changes in the perichondrial arterioles. Although dated, this vasculitis/inflammatory theory, first proposed by Halter in 1936 [62], is still the most widely accepted explanation for CNH. More recently, it was supported by Upile et al. in 2009 [23], with a histopathological review of 16 cases. Upile et al. confirmed the previous findings of epidermal acanthosis associated with a horny, partly parakeratotic, plug or ulceration and scale crust, superficial debris with fibrin, sclerosis, perichondrial fibrosis, and a varying degree of cartilage degeneration closely associated with areas of granulation tissue (see Figure 2). Upile et al. also confirmed the presence of consistent arteriolar narrowing in the part of the perichondrium most remote from the arterial blood supply, that is, the helix. This leads to ischemic changes and death of the metabolically active underlying cartilage with necrosis and extrusion and to severe local inflammation secondary to a foreign body reaction [23]. Furthermore, nerve hyperplasia is present in CNH, though often masked by the intense vascular and inflammatory reactions, which may explain the characteristic exquisite tenderness [10].

(a)

(b)

A possible association with systemic disease, such as dermatomyositis and systemic sclerosis, has also been suggested [11]. However, it is more likely that immobility caused by these diseases, and hence the inability to alter sleeping position, could be the true cause of a correlation between CNH and systemic disease.

3.4. Differential Diagnosis

The differential diagnosis depends on the clinical presentation, but the location of the lesion in combination with exquisite tenderness helps to differentiate CNH from other diagnoses. Gouty tophi may be suspected, when there are multiple lesions, not only on the ear, but also on fingers and toes. The nodular appearance with a central ulceration can mimic a basal cell carcinoma, while larger and more inflamed lesions may look like a squamous cell carcinoma, one of the most common misdiagnoses of CNH. Keratoacanthoma usually exhibits much faster growth, resulting in a larger tumour volume and with the classic resolution over months. When keratosis is the predominant clinical feature, an actinic or seborrheic keratosis may be suspected. However, only histopathological examination of a deep biopsy can secure the diagnosis and definitely rule out malignancy.

3.5. Treatment

In general, the scientific work on the treatment of CNH lacks large, randomised, controlled studies. Historically, surgical excision (Table 3) has been more frequently investigated and the preferred treatment modality [1, 8, 22, 24, 26, 32–35, 39, 50]. Recently, however, more conservative methods have been investigated in an effort to avoid the discomfort of surgery, the risk of postoperative infections, and problems with wound healing and deformity (Table 1).

3.5.1. Pressure Relieving Padding

The repeated observation that CNH usually affects the ear on the preferred sleeping-side suggests that pressure on the ear is an important aetiological factor. This leads to the logical conclusion that relieving pressure on the ear will be a successful treatment. Seven studies, including 148 patients treated with pressure-relieving padding alone, were identified (Table 1). Many of the studies on other treatment modalities also recommend decompression of the ear after treatment, making this a major confounding factor. Half of the studies on pressure relieving padding were prospective, but none were randomized or controlled. Several methods were described, including self-adhering foam behind the ear, foam bandages strapped to the head, and sleeping on a doughnut-shaped pillow. All aimed to provide a means for relieving the pressure on the affected area of the ear. The cure rate reported in the pure decompression studies was as low as 57% and as high as 92%. In 2011 Durrant et al. published a prospective study on 75 patients treated with a customised ear prosthesis [12] where 47% experienced complete resolution and 27% improvement. After more than 6 months, 31% experienced recurrence, but overall 91% of the patients avoided surgery [12]. Considering all the studies on pressure relieving padding, we conclude that this conservative treatment-approach is inexpensive and cost-effective but that the result depends very much on the compliance of the patient.

3.5.2. Topical Nitroglycerin

As CNH may result from chondrial ischemia arising from perichondrial arteriolar narrowing and nitroglycerin causes relaxation and vasodilation of the arteriolar smooth muscle, this treatment may restore adequate blood flow to reverse the ischemic changes [15]. Four studies totalling 53 patients treated with topical nitroglycerin were identified (Table 1). Forty-two patients were treated with nitroglycerin gel applied once or twice daily for up to three months and 11 patients were treated with a transdermal nitroglycerin patch, 12 hours a day for two months. Of the latter, two patients stopped the treatment due to moderate headaches and one patient only had a partial response and later underwent surgery, leaving 64% who had a complete response. Of the former, a 93% and 92% cure rate was reported. Topical nitroglycerin is usually used in the treatment of angina pectoris or chronic anal fissures and the most common side effect is transient headaches. Skin irritation has also been reported. Due to the low systemic absorption from the ear, topical treatment should not cause any major side effects [15]. We conclude that this treatment modality shows promising results, but further studies, with larger numbers of patients, are needed.

3.5.3. Glucocorticoid Injection

As explained above, the aetiology of CNH probably includes local inflammation secondary to a foreign body reaction. Glucocorticoids are potent anti-inflammatory agents and should be able to stop the local inflammation. Three studies on intralesional injection of glucocorticoid were identified, one prospective (Table 1). A study by Lawrence from 1991 was actually a study of the effectiveness of surgery, but 44 patients first received intralesional steroid injections and those who had not responded after 8 weeks (73%) were then offered surgery [8]. Also noteworthy is the study by Cox and Denham from 2002 [29], who retrospectively reported the outcomes of 60 patients treated with one dose of 0,1 mL of intralesional triamcinolone, demonstrating a 40% response at three months. Four patients later required a second injection and were then symptom-free. Another four patients had late recurrence, decreasing the long-term success rate to 33%, after follow-up of up to eight years [29]. Although this treatment is easy, fast, and inexpensive, we do not feel it should be recommended as first line treatment, due to the low cure rates.

3.5.4. Injectable Collagen

Greenbaum reported on the outcome of treatment for 5 patients in 1991, who received injections of collagen over the perichondrium to relieve pressure on the cartilage (Table 1). The cure rate was reported to be 100% after a follow-up period of 0–16 months [17]. However, such results are inconclusive due to the small number of patients and relative short period of follow-up.

3.5.5. PDT

It is thought that PDT acts on several pathways involved in CNH: it has an anti-inflammatory and immunomodulatory action, an effect on vascularisation and on collagen and it may also have a chondroprotective effect [30]. Treatment with aminolevulinic acid- (ALA-) PDT seems to slow the inflammatory reaction in the skin, because of the death of the resident macrophages and mast cells and the slow recovery to cytokine responsiveness of the surviving cell population. Although it is generally accepted that PDT causes acute inflammation, it can also interrupt the process of chronic inflammation and stimulate healing [30]. It has been shown that blood perfusion is increased immediately after irradiation and this persists for up to one week. It has also been shown that chondrocytes are not destroyed, but that PDT modulates in vitro cartilage metabolism, activating a chondroprotective effect in photosensitized cartilage in the context of osteoarthritis [30]. Two studies, involving only seven patients treated with PDT, were identified (Table 2). Gilaberte et al. reported on five patients treated with PDT, after preparing the site with curettage to scrape away crusts, and so forth. The cure rate was reported to be 80%, although the period of follow-up was not reported [30]. These results should be considered inconclusive because of the very small numbers of patients treated and the limited follow-up.

3.5.6. CO₂ and Argon Laser

Only two studies, comprising 14 patients, were identified [19, 38] (Table 2). Patients received treatment with a CO₂ laser and their wounds were allowed to heal by secondary intention. However, they were also instructed to decompress their ears for 3-4 weeks. The cure rate was reported as 100%, after a follow-up period of 2–24 months. One study reported on the outcomes of nine patients treated with argon laser, with a 56% cure rate [18]. The small number of patients in these studies makes it difficult to form any definite conclusion, though the high cure rates warrant further studies.

3.5.7. Curettage/Electrocauterization

Kromann et al. published the most comprehensive study of a nonsurgical treatment for CNH in 1983 [21] (Table 2). They reported the outcomes of 142 cases during a 15-year period who were treated with curettage followed by electrocauterization. Fifteen patients also underwent treatment with radiotherapy after curettage. A further five patients were treated with radiotherapy alone, with no effect, and then proceeded to curettage with electrocauterization. An unknown number received treatment with intralesional triamcinolone injections and freezing with carbon dioxide in addition to curettage. Seventy-eight patients were reexamined after an average of 7.1 years and 31% were found to have relapsed. An overall recurrence rate of 25% was reported, but after an unknown follow-up [21]. Although curettage appears to have an acceptable cure and recurrence rate, there are many confounding variables, making it difficult to know with certainty whether curettage alone was responsible for the “cures” achieved. Moreover, there have been no other studies of this treatment since 1983.

3.5.8. Surgery

Many techniques have been described and most agree that a simple approach, with primary excision and meticulous trimming of the cartilage, is the preferred method [8, 11, 22, 24, 26, 32–35, 39, 43, 50].

Seventeen surgical studies, including more than 500 patients, were reviewed (Table 3). The surgical techniques described include wide excision with reconstruction of the ear using local flaps, skin grafts, excision of the affected skin and underlying cartilage, and skin-sparing techniques with excision of the cartilage only.

The cure rates reported range from 66% to 100% with a recurrence rate of up to 38%. In this review, recurrences were most frequent at the edges of the cartilage defect. Therefore, later studies advised greater attention to careful trimming of all affected cartilage.

In 1991, Lawrence [8] described a surgical technique to remove only the affected cartilage under a skin flap. With a cure rate of 88% and a recurrence rate of 12% this technique proved to be as efficient as any other at the time and has since been described in various modifications in an effort to simplify the procedure [8].

In 2014, Kulendra et al. described a method used to treat 59 patients [31]. On the helix, a skin incision was made which was 2-3 times the diameter of the nodule, 1-2 mm wide, and tapered to a point. The nodule and adjacent area were excised and sent for histology. The exposed, raised cartilage was gradually removed at the centre, using a surgical blade, sharp-pointed-scissors, or a diamond burr. The wound was then closed directly with interrupted sutures. On the antihelix, access to the nodule was achieved through an anterior interhelical and inferior releasing incision, elevating a skin flap with perichondrium to expose the cartilage. The nodule and surrounding cartilage were excised, avoiding sharp edges and removing any of the remaining antihelix to a height lower than the helix. The skin flap was then scarified and sutured back in place. These techniques resulted in a cure rate of 88% for the helix and 89% for the antihelix after a follow-up of 85 months [31].

Some authors stress the importance of sending material, including skin, for histology to confirm the diagnosis and rule out malignancy. Rajan and Langtry, 2007 [32], support this argument and recommend their “punch and graft technique” used on 22 patients with a cure rate of 83% after a follow-up of 1–86 months. A punch biopsy instrument, with a diameter large enough to encompass the lesion, was used to cut the skin and the underlying cartilage. The specimen was then excised with scissors or blade and sent for histology. The same punch tool was used to harvest a full thickness skin graft from the postauricular area and the graft fixed in place with 6-0 interrupted sutures [32].

4. Conclusion

Even though CNH is not life threatening, it can impair quality of life. The incidence and prevalence is not known, but the disease appears to be common. Historically, a preponderance for males has been reported but in this review, we found a more equal gender distribution.

The vasculitis/inflammatory theory is most widely supported and explains the development of the lesion by arteriolar narrowing in the perichondrium leading to ischemic changes in the cartilage, followed by necrosis and extrusion of the necrotic material. This theory is further supported by the effectiveness of therapies aimed at improvement of the blood supply and/or dilation of blood vessels. One such therapy is topical nitroglycerin, which shows promising results, but larger studies are still warranted.

Much attention has recently been paid to decompression therapy and this seems to be a cost-effective therapy with acceptable cure rates but obviously depends on the compliance of the patient.

Multiple other therapies have been investigated, but in order to establish guidelines for the best treatment of CNH, larger, prospective, controlled, and randomised long-term studies are still required.

Based on the available literature however, we suggest first-line treatment with decompression devices and only if these are not effective surgical treatment. The surgical method recommended should be with minimal skin excision, primarily for histology, excision of the affected cartilage with careful trimming of the cartilage edges, and when possible direct skin closure, otherwise a skin graft.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

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Copyright

Copyright © 2016 Lea Juul Nielsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Therapeutic Options of Chondrodermatitis Nodularis Helicis

Abstract

1. Introduction

2. Method and Material

3. Results

3.1. Clinical Presentation

3.2. Gender and Age Distribution

3.3. Pathogenesis

3.4. Differential Diagnosis

3.5. Treatment

3.5.1. Pressure Relieving Padding

3.5.2. Topical Nitroglycerin

3.5.3. Glucocorticoid Injection

3.5.4. Injectable Collagen

3.5.5. PDT

3.5.6. CO2 and Argon Laser

3.5.7. Curettage/Electrocauterization

3.5.8. Surgery

4. Conclusion

Conflict of Interests

References

Copyright

3.5.6. CO₂ and Argon Laser