Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder

Table 1

Results of patients’ cognitive assessment prior to and during treatment with SSRs (number of patients = 50).

Weeks of treatment	Week 0	Week 3	Week 5	Week 8
Mean MMSE score	23.94	22.1	21.4	20.66
p values of comparing MMSE scores of weeks 3, 5, and 8 with baseline score	—	<0.0001	<0.0001	<0.0001
p values of comparing MMSE scores of weeks 5 and 8 with the results of week 3	—	—	<0.0001	0.0709
p values of comparing MMSE scores of week 8 with the results of week 5	—	—	—	<0.0001

The trend of decline shows faster decline by 5 weeks and a more subtle decline until week 8.