The Temporal Relationship between Selected Mental Disorders and Substance-Related Disorders: A Nationwide Population-Based Cohort Study

Table 5

Estimated hazard ratio of the subsequent onset of each subtype of SRDs for those with the selected mental disorders compared to those without, adjusted for age, gender, urban, and income levels.

Dependent variable	HR	(95% CI)	p-value
Independent variable
Alcohol-induced mental disorders
Neurotic disorders	8.75	(6.78-11.29)	<.0001
Affective psychoses	64.75	(26.76-156.68)	<.0001
Adjustment reaction	12.59	(3.88-40.90)	<.0001
Schizophrenia	30.62	(7.48-125.31)	<.0001
Personality disorders	38.64	(5.29-282.15)	0.0003
Drug-induced mental disorders
Neurotic disorders	11.47	(7.99-14.47)	<.0001
Affective psychoses	26.88	(13.27-54.48)	<.0001
Adjustment reaction	14.39	(4.47-46.40)	<.0001
Schizophrenia	22.51	(7.07-71.65)	<.0001
Personality disorders	60.77	(8.41-439.17)	<.0001
Alcohol dependence syndrome
Neurotic disorders	6.98	(5.89-8.29)	<.0001
Affective psychoses	22.1	(14.91-32.75)	<.0001
Adjustment reaction	21.56	(7.91-58.82)	<.0001
Schizophrenia	17.82	(7.23-43.91)	<.0001
Personality disorders	47.3	(11.64-192.22)	<.0001
Drug dependence
Neurotic disorders	25.32	(16.19-39.60)	<.0001
Affective psychoses	47.25	(21.05-106.08)	<.0001
Adjustment reaction	68.02	(9.44-490.12)	<.0001
Schizophrenia	64.71	(8.97-466.70)	<.0001
Personality disorders	82.4	(11.45-592.81)	<.0001
Nondependent abuse of drugs
Neurotic disorders	3.75	(3.41-4.13)	<.0001
Affective psychoses	7.07	(5.83-8.58)	<.0001
Personality disorders	6.07	(4.12-8.94)	<.0001
Schizophrenia	9.37	(5.83-15.06)	<.0001
Personality disorders	22.63	(10.59-48.35)	<.0001