Assessment of Real-Life Outcomes in Schizophrenia Patients according to Compliance
Table 2
Patient clinical characteristics and hospitalizations.
Overall
Sometimes compliant
Always compliant
value (testa)
Response to the current treatment regimen
1236
644
592
Inadequate responder
387 (31.3)
269 (41.8)
118 (19.9)
<0.001 (FE)
Responder
849 (68.7)
375 (58.2)
474 (80.1)
CGI overall impression of severity of illness
1334
700
634
Mild
339 (25.4)
133 (19.0)
206 (32.5)
<0.001 (CH)
Moderate
820 (61.5)
444 (63.4)
376 (59.3)
Severe
175 (13.1)
123 (17.6)
52 (8.2)
Current symptoms present
1342
706
636
Positive
1114 (83.0)
619 (87.7)
495 (77.8)
<0.001 (FE)
Negative
1168 (87.0)
628 (89.0)
540 (84.9)
0.028 (FE)
Cognitive impairments
956 (71.2)
539 (76.3)
417 (65.6)
<0.001 (FE)
Anxiety
918 (68.4)
515 (72.9)
403 (63.4)
<0.001 (FE)
Depression
757 (56.4)
396 (56.1)
361 (56.8)
0.826 (FE)
Sleep issues
493 (36.7)
293 (41.5)
200 (31.4)
<0.001 (FE)
Other
302 (22.5)
185 (26.2)
117 (18.4)
<0.001 (FE)
Overall severity, positive symptomsb
1326
699
627
Mean (SD)
45.5 (29.4)
51.7 (28.5)
38.6 (28.8)
<0.001 (TT)
Overall severity, negative symptomsb
1328
701
627
Mean (SD)
41.3 (24.3)
45.0 (24.6)
37.1 (23.3)
<0.001 (TT)
Overall severity, cognitive symptomsb
1327
701
626
Mean (SD)
31.8 (24.4)
35.9 (24.8)
27.1 (23.0)
<0.001 (TT)
Number of concomitant conditions
1336
704
632
Mean (SD)
2.1 (2.1)
2.3 (2.1)
2.0 (2.1)
0.007 (TT)
Concomitant conditions
1336
704
632
Anxiety
330 (24.7)
184 (26.1)
146 (23.1)
0.204 (FE)
Hypertension
344 (25.7)
194 (27.6)
150 (23.7)
0.117 (FE)
Depression
257 (19.2)
138 (19.6)
119 (18.8)
0.729 (FE)
Obesity
230 (17.2)
125 (17.8)
105 (16.6)
0.612 (FE)
Dyslipidemia
229 (17.1)
120 (17.0)
109 (17.2)
0.942 (FE)
Stress
185 (13.8)
115 (16.3)
70 (11.1)
0.006 (FE)
Insomnia
132 (9.9)
86 (12.2)
46 (7.3)
0.003 (FE)
Diabetes
136 (10.2)
73 (10.4)
63 (10.0)
0.856 (FE)
Hospitalized because of disease in the last 12 months
1314
693
621
Hospitalized
342 (26.0)
246 (35.5)
96 (15.5)
<0.001 (FE)
Number of hospitalizations in the last 12 monthsc
278
203
75
Mean (SD)
1.5 (1.0)
1.6 (0.9)
1.5 (1.2)
0.597 (TT)
Caregiver status
, physician-reported
1240
648
592
Has caregiver
444 (35.8)
255 (39.4)
189 (31.9)
0.008 (FE)
, patient-reported
605
318
287
Has caregiver
214 (35.4)
118 (37.1)
96 (33.4)
0.351 (FE)
CGI = Clinical Global Impression; CH = chi-squared test; FE = Fisher’s exact test; SD = standard deviation; TT = Student’s -test. aStatistical test performed. bRated from 0 (not present) to 100 (severe). cOnly patients who were hospitalized were included. All data reported as (%) unless indicated otherwise.
