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Rehabilitation Research and Practice
Volume 2012, Article ID 506387, 5 pages
http://dx.doi.org/10.1155/2012/506387
Clinical Study

The Use of NeuroAiD (MLC601) in Postischemic Stroke Patients

Stroke Unit, Department of Neurology and Psychiatry, University of Santo Tomas Hospital, España Boulevard, San Vicente Ferrer Ward, 1008 Manila, Philippines

Received 22 August 2012; Revised 29 October 2012; Accepted 12 November 2012

Academic Editor: K. S. Sunnerhagen

Copyright © 2012 Jose C. Navarro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. We aimed to assess the efficacy of MLC601 on functional recovery in patients given MLC601 after an ischemic stroke. Methods. This is a retrospective cohort study comparing poststroke patients given open-label MLC601 ( ; 9 female) for three months and matching patients who did not receive MLC601 from our Stroke Data Bank. Outcome assessed was modified Rankin Scale (mRS) at three months and analyzed according to: (1) achieving a score of 0-2, (2) achieving a score of 0-1, and (3) mean change in scores from baseline. Results. At three months, 21 patients on MLC601 became independent as compared to 17 patients not on MLC601 (OR 1.79; 95% CI 0.62–5.2; ). There were twice as many patients ( ) on MLC601 who attained mRS scores similar to their prestroke state than in the non-MLC601 group ( ) (OR 3.14; 95% CI 1.1–9.27; ). Mean improvement in mRS from baseline was better in the MLC601 group than in the non-MLC601 group (−1.7 versus −0.9; mean difference −0.73; 95% CI −1.09 to −0.38; ). Conclusion. MLC601 improves functional recovery at 3 months postischemic stroke. An ongoing large randomized control trial of MLC601 will help validate these results.