Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke
Table 2
ANOVA table for (a) time, (b) treatment group, and (c) time × treatment interaction for A-prime, reaction time, DETECT -score, grip strength, BBT, CES-D, and SIS categories. There was a significant main effect of time on reaction time, DETECT -score, grip strength of the affected hand, and CES-D score. There was a significant main effect of treatment group on grip strength of the unaffected hand only. There was a significant time × treatment group interaction for SIS overall stroke recovery rating only.
(a) Repeated measures ANOVA (per visit) across all subjects
Source
-RFDR
A-prime
2.852
0.119
0.225
0.206
Reaction time
10.765
0.007
0.014
0.495
DETECT -score
7.026
0.026
0.050
0.438
Grip strength, affected hand
19.839
0.001
0.002
0.643
Grip strength, unaffected hand
5.331
0.041
0.078
0.326
BBT, affected hand
0.022
0.884
1.670
0.002
BBT, unaffected hand
4.816
0.051
0.096
0.305
CES-D score
6.330
0.029
0.054
0.365
Stroke Impact Scale Category
Strength
0.414
0.533
1.007
0.036
Memory
5.594
0.037
0.071
0.337
Mood
7.653
0.018
0.035
0.410
Communication
0.634
0.443
0.836
0.055
ADL/IADL
4.133
0.067
0.126
0.273
Mobility
0.649
0.438
0.826
0.056
Hand function
5.325
0.041
0.078
0.326
Participation
2.810
0.122
0.230
0.203
Stroke recovery
0.971
0.346
0.623
0.081
(b) Repeated measures ANOVA (per group)
Source
-RFDR
A-prime
2.424
0.148
0.279
0.181
Reaction time
0.316
0.586
1.106
0.028
DETECT -score
0.000
1.000
1.889
0.000
Grip strength, affected hand
1.493
0.247
0.467
0.120
Grip strength, unaffected hand
8.407
0.014
0.026
0.433
BBT, affected hand
0.043
0.840
1.587
0.004
BBT, unaffected hand
0.308
0.590
1.115
0.027
CES-D score
2.988
0.112
0.211
0.214
Stroke Impact Scale Category
Strength
0.287
0.603
1.139
0.025
Memory
0.141
0.714
1.349
0.013
Mood
1.841
0.202
0.382
0.143
Communication
0.093
0.767
1.448
0.008
ADL/IADL
0.009
0.924
1.746
0.001
Mobility
0.691
0.424
0.800
0.059
Hand function
0.211
0.655
1.237
0.019
Participation
2.793
0.123
0.232
0.203
Stroke recovery
2.909
0.166
0.299
0.209
(c) Repeated measures ANOVA (time × group interaction) across all subjects
