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Radiology Research and Practice
Volume 2011 (2011), Article ID 586785, 8 pages
http://dx.doi.org/10.1155/2011/586785
Clinical Study

The Severity of Fatty Liver Disease Relating to Metabolic Abnormalities Independently Predicts Coronary Calcification

1Cardiovascular Medicine, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan
2Department of Medicine, Mackay Medical College, Taipei, Taiwan
3Department of Medicine, Mackay Medicine, Nursing and Management College, Taipei, Taiwan
4Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan
5Health Evaluation Center, Mackay Memorial Hospital, Taipei 10449, Taiwan
6The Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan
7Department of Medical Technology, Yuanpei University of Science and Technology, Hsin-Chu, Taiwan
8Department of Health Industry Management, Kainan University, Taoyuan, Taiwan

Received 21 July 2011; Accepted 22 September 2011

Academic Editor: Paul E. Kinahan

Copyright © 2011 Ying-Hsiang Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Nonalcoholic fatty liver disease (NAFLD) is one of the metabolic disorders presented in liver. The relationship between severity of NAFLD and coronary atherosclerotic burden remains largely unknown. Methods and Materials. We analyzed subjects undergoing coronary calcium score evaluation by computed tomography (MDCT) and fatty liver assessment using abdominal ultrasonography. Framingham risk score (FRS) and metabolic risk score (MRS) were obtained in all subjects. A graded, semiquantitative score was established to quantify the severity of NAFLD. Multivariate logistic regression analysis was used to depict the association between NAFLD and calcium score. Results. Of all, 342 participants (female: 22.5%, mean age: years) met the sufficient information rendering detailed analysis. The severity of NAFLD was positively associated with MRS ( , trend ) and FRS ( , trend ). After multivariable adjustment for clinical variables and life styles, the existence of moderate to severe NAFLD was independently associated with abnormal calcium score ( ). Conclusion. The severity of NAFLD correlated well with metabolic abnormality and was independently predict coronary calcification beyond clinical factors. Our data suggests that NAFLD based on ultrasonogram could positively reflect the burden of coronary calcification.