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Radiology Research and Practice
Volume 2016, Article ID 4801474, 16 pages
Review Article

Calcium Apatite Deposition Disease: Diagnosis and Treatment

Department of Diagnostic and Interventional Imaging, UT Health, Houston, TX, USA

Received 28 September 2016; Accepted 24 October 2016

Academic Editor: Ali Guermazi

Copyright © 2016 Nicholas M. Beckmann. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Calcium apatite deposition disease (CADD) is a common entity characterized by deposition of calcium apatite crystals within and around connective tissues, usually in a periarticular location. CADD most frequently involves the rotator cuff. However, it can theoretically occur in almost any location in the musculoskeletal system, and many different locations of CADD have been described. When CADD presents in an unexpected location it can pose a diagnostic challenge, particularly when associated with pain or swelling, and can be confused with other pathologic processes, such as infection or malignancy. However, CADD has typical imaging characteristics that usually allows for a correct diagnosis to be made without additional imaging or laboratory workup, even when presenting in unusual locations. This is a review of the common and uncommon presentations of CADD in the appendicular and axial skeleton as well as an updated review of pathophysiology of CADD and current treatments.