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Radiology Research and Practice
Volume 2016 (2016), Article ID 9305018, 7 pages
Research Article

Novel Pattern of Iron Deposition in the Fascicula Nigrale in Patients with Parkinson’s Disease: A Pilot Study

1Department of Radiology, School of Medicine, Loma Linda University, 11234 Anderson Street, Loma Linda, CA 92354, USA
2Department of Neurology, School of Medicine, Loma Linda University, 11234 Anderson Street, Loma Linda, CA 92354, USA

Received 7 March 2016; Revised 31 May 2016; Accepted 31 May 2016

Academic Editor: Paul Sijens

Copyright © 2016 Miriam E. Peckham et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Purpose. To determine whether the pattern of iron deposition in the fascicula nigrale in patients with Parkinson’s disease would be different from age-matched controls by utilizing quantitative susceptibility mapping to measure susceptibility change. Methods. MRIs of the brain were obtained from 34 subjects, 18 with Parkinson’s disease and 16 age- and gender-matched controls. Regions of interest were drawn around the fascicula nigrale and substantia nigra using SWI mapping software by blinded investigators. Statistical analyses were performed to determine susceptibility patterns of both of these regions. Results. Measurements showed significantly increased susceptibility in the substantia nigra in Parkinson’s patients and an increased rostral-caudal deposition of iron in the fascicula nigrale in all subjects. This trend was exaggerated with significant correlation noted with increasing age in the Parkinson group. Conclusion. The pattern of an exaggerated iron deposition gradient of the fascicula nigrale in the Parkinson group could represent underlying tract dysfunction. Significant correlation of increasing iron deposition with increasing age may be a cumulative effect, possibly related to disease duration.