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Volume 1, Issue 3-4, Pages 183-187
Case Report

Multi-Focal, Multi-Centric Angiosarcoma of Bone

1The London Soft Tissue & Bone Tumour Service, The Meyerstein Institute of Oncology, The Middlesex Hospital, Mortimer Street, London W1N 8AA, UK
2Kent and Canterbury Hospital, Canterbury, Kent, UK
3Department of Histopathology, University College Hospital, London, UK

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A multi-focal multi-centric, malignant tumour of vascular origin arising in bone in a 55-year-old man is described. The presenting symptoms were pain and weight loss. Radiologically, multiple lytic lesions were demonstrated in the long bones of both legs and throughout the pelvis. Histological examination demonstrated an angiosarcoma which was predominantly low grade in nature but with focal areas of intermediate grade. Turnout cells expressed the endothelial markers CD31, CD34 and von Willebrand's factor. There was rapid radiological progression of disease with no response to radiotherapy. Pain abated within a few days of institution of doxorubicin, 75 mg m−2, but the patient died of massive pulmonary thromboembolism 14 days later, 11 months after the first symptoms.