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Volume 3, Issue 2, Pages 95-99

Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma

1Section of Hematology-Oncology, Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC2115, Chicago 60637, IL, USA
2Section of Endocr inology, Department of Medicine, University of Chicago, Chicago 60637, IL, USA

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Discussion. Oncogenic osteomalacia is a rare paraneoplastic syndrome of skeletal demineralization from renal phosphate loss. Patients with this disorder have the characteristic clinical, laboratory, and radiographic findings of hyperphosphaturic osteomalacia. Although the pathophysiology has not yet been clearly delineated, a humoral factor produced by the tumor is suspected to be the cause.

Purpose. We report the first case of oncogenic osteomalacia that improved with chemotherapy, discuss this paraneoplastic syndrome, and review the medical literature regarding its etiology.