Table of Contents Author Guidelines Submit a Manuscript
Sarcoma
Volume 6, Issue 4, Pages 141-143
http://dx.doi.org/10.1080/1357714021000066395
Case Report

Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a Patient with Turner Syndrome Mosaic

1Division of Pneumology, Department of Medicine, University Hospital Leipzig, Leipzig, Germany
2Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
3Division of Thoracic Surgery, Department of Surgery, University Hospital Leipzig, Leipzig, Germany
4Institute of Human Genetics, University Hospital Leipzig, Leipzig, Germany
5Department of Internal Medicine III, University Hospital Leipzig, Philipp-Rosenthal-Str. 27, Leipzig 04103, Germany

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We describe a patient who underwent thoracic radiation therapy for biopsy-proven pulmonary spindle cell sarcoma in the left lower lobe, 15 months after birth. At the age of 37 she developed shoulder pain, fatigue, and progressive exertion dyspnoea. Chest X-ray revealed a pulmonary mass in the left lower lobe due to a cytology-proven malignant tumour.The patient underwent left pneumonectomy. Histology revealed a myosarcoma of the lung, similar to the previous sarcoma. Furthermore, the patient was diagnosed to have Turner syndrome mosaic and chromosomal analysis revealed a translocation t(1;13) in 3/50 metaphases. However a germline mutation of the p53 tumour suppressor gene was excluded. After 2 years of follow-up the patient is stable and there are no signs of recurrence of the tumour.We conclude a re-occurrence of this very rare malignant disorder of the lung after a 36-year interval in a patient with Turner syndrome mosaic. Following initial curative radiation therapy, with a remission over 36 years, lung resection was now successfully performed.