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Sarcoma
Volume 7, Issue 3-4, Pages 149-152
http://dx.doi.org/10.1080/13577140310001644760

Treatment of Epithelioid Sarcoma at the Royal Marsden Hospital

1Radiotherapy Department, Florence University, Florence, Italy
2Mount Vernon Cancer Centre, Northwood HA6 2RN, UK
3Sarcoma Unit, Royal Marsden Hospital, Fulham Road, SW3 6JJ, UK
4Department of Clinical Oncology, Florence University, Viale Morgagni 85, Florence 50134, Italy

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose: The aim of this study was to assess treatment and outcome with respect to clinical and pathological features.

Patients and methods: Thirty-nine patients were identified (range 7–66 years, mean 23). Initial treatment comprised local excision in 11 patients and wide excision in 14. Post-operative external beam radiotherapy was prescribed in 22 patients with a total dose of 60 Gy, delivered in two phases.

Results: The cause-specific survival for the entire group was 79, 63, 56 and 45% at 1, 3, 5 and 10 years, respectively. A distal limb location was associated with a better prognosis than proximal limb location (P = 0.04).

Conclusions: Our data favour treatment with wide functional excision followed by radical dose radiotherapy in attempt to minimize risk of local recurrence, especially when primary tumours are bigger than 3 cm. Our data also suggest the same treatment for local recurrence, when technically possible, to avoid amputation.