Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature

Hussain, Sakeer; Nanda, Anil; Fowler, Marjorie; Ampil, Federico L.; Burton, Gary V.

doi:https://doi.org/10.1155/SRCM/2006/52140

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Case Report | Open Access

Volume 2006 | Article ID 052140 | https://doi.org/10.1155/SRCM/2006/52140

Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature

Sakeer Hussain,¹Anil Nanda,²Marjorie Fowler,³Federico L. Ampil,⁴and Gary V. Burton¹

Received29 Jun 2006

Revised13 Oct 2006

Accepted13 Oct 2006

Published20 Dec 2006

Abstract

A 26-year old man presented with a 3-month history of a progressively enlarging palpable parieto-occipital mass. A CT scan indicated the lesion arose from the dura with bony destruction. A stealth assisted craniotomy was performed with the provisional diagnosis of osteoblastic meningioma. Further histopathologic analysis of the intracranial mass was consistent with leiomyosarcoma. Staging evaluation, including CT and PET scans, demonstrated no other sites of disease. Despite complete surgical resection and radiotherapy to the resection site, the disease recurred locally and systematically 5 months later. Primary intracranial mesenchymal tumors are rare and few cases have been previously reported. Outcomes have been universally poor and current therapeutic approaches appear to have only limited benefit.

References

J Weitz, C R Antonescu, and M F Brennan, “Localized extremity soft tissue sarcoma: improved knowledge with unchanged survival over time,” Journal of Clinical Oncology, vol. 21, no. 14, pp. 2719–2725, 2003.
View at: Publisher Site | Google Scholar
W Paulus, F Slowik, and K Jellinger, “Primary intracranial sarcomas: histopathological features of 19 cases,” Histopathology, vol. 18, no. 5, pp. 395–402, 1991.
View at: Google Scholar
T T Lee and L K Page, “Primary cerebral leiomyosarcoma,” Clinical Neurology and Neurosurgery, vol. 99, no. 3, pp. 210–212, 1997.
View at: Publisher Site | Google Scholar
I Feigin, L Allen, L Lipkon, and S. W. Gross, “The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation,” Cancer, vol. 11, no. 2, pp. 264–277, 1957.
View at: Publisher Site | Google Scholar
H G Brown, P C Burger, A Olivi, A K Sills, P.A Barditch-Crovo, and R R Lee, “Intracranial leiomyosarcoma in a patient with AIDS,” Neuroradiology, vol. 41, no. 1, pp. 35–39, 1999.
View at: Publisher Site | Google Scholar
G K Bejjani, B Stopak, A Schwartz, and R Santi, “Primary dural leiomyosarcoma in a patient infected with human immunodeficiency virus: case report,” Neurosurgery, vol. 44, no. 1, pp. 199–202, 1999.
View at: Google Scholar
J Niwa, K Hashi, and T Minase, “Radiation induced intracranial leiomyosarcoma: its histopathological features,” Acta Neurochirurgica, vol. 138, no. 12, pp. 1470–1471, 1996.
View at: Publisher Site | Google Scholar
B Pasquier, P Couderc, D Pasquier et al., “Les tumeurs ‘musculaires’ ou a composante myosarcomateuse primitives du systeme nerveux central,” Semaine des Hopitaux de Paris, vol. 53, no. 36, pp. 1927–1940, 1977.
View at: Google Scholar
N J Espat, M Bilsky, J J Lewis, D Leung, and M F Brennan, “Soft tissue sarcoma brain metastases: prevalence in a cohort of 3829 patients,” Cancer, vol. 94, no. 10, pp. 2706–2711, 2002.
View at: Publisher Site | Google Scholar
H A Haykal, A M Wang, and A Zamani, “Leiomyosarcoma metastatic to the brain: CT features and review,” American Journal of Neuroradiology, vol. 8, no. 5, pp. 911–912, 1987.
View at: Google Scholar
D N Louis, E P Jr Richardson, G R Dickersin, D A Petrucci, A E Rosenberg, and R G Ojemann, “Primary intracranial leiomyosarcoma. Case report,” Journal of Neurosurgery, vol. 71, no. 2, pp. 279–282, 1989.
View at: Google Scholar

Copyright

Copyright © 2006 Sakeer Hussain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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