Sarcoma

Sarcoma / 2006 / Article

Case Report | Open Access

Volume 2006 |Article ID 053901 | https://doi.org/10.1155/SRCM/2006/53901

Verity A. Currall, John H. Dixon, "Synchronous Multifocal Osteosarcoma: Case Report and Literature Review", Sarcoma, vol. 2006, Article ID 053901, 3 pages, 2006. https://doi.org/10.1155/SRCM/2006/53901

Synchronous Multifocal Osteosarcoma: Case Report and Literature Review

Received03 Feb 2006
Accepted12 Jul 2006
Published03 Sep 2006

Abstract

Background. Multifocal osteosarcoma is usually described as the occurrence of the tumour at two or more sites in a patient without pulmonary metastases and may be synchronous or metachronous. Case report. A previously well 21-year old male, who presented with a swollen, painful right knee with no history of trauma, was found to have a high-grade osteosarcoma of the distal tibia and proximal femur. He underwent resection and prosthetic replacement of the distal femur and proximal tibia and remains well 19 months after diagnosis. Discussion. Multifocal osteosarcoma is a rare condition with a poor prognosis. There is debate about whether it represents multiple primary tumours or metastatic disease.

References

  1. G Silverman, “Multiple osteogenic sarcoma,” Archives of Pathology, vol. 21, pp. 88–95, 1936. View at: Google Scholar
  2. R H Daffner, S L Kennedy, K R Fox, J J Crowley, D D Sauser, and L A Cooperstein, “Synchronous multicentric osteosarcoma: the case for metastases,” Skeletal Radiology, vol. 26, no. 10, pp. 569–578, 1997. View at: Publisher Site | Google Scholar
  3. H C Amstutz, “Multiple osteogenic sarcomata - metastatic or multicentric? Report of two cases and review of literature,” Cancer, vol. 24, no. 5, pp. 923–931, 1969. View at: Publisher Site | Google Scholar
  4. D M Parham, C B Pratt, L S Parvey, B L Webber, and J Champion, “Childhood multifocal osteosarcoma. Clinicopathologic and radiologic correlates,” Cancer, vol. 55, no. 11, pp. 2653–2658, 1985. View at: Publisher Site | Google Scholar
  5. R J McKenna, C P Schwinn, K Y Soong, and N L Higinbotham, “Sarcomata of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): an analysis of 552 cases,” The Journal of Bone and Joint Surgery. American Volume, vol. 48, pp. 1–26, 1966. View at: Google Scholar
  6. D C Dahlin and M B Coventry, “Osteogenic sarcoma. A study of six hundred cases,” The Journal of Bone and Joint Surgery. American Volume, vol. 49, no. 1, pp. 101–110, 1967. View at: Google Scholar
  7. R D Jones, R Reid, G Balakrishnan, and A Barrett, “Multifocal synchronous osteosarcoma: the Scottish Bone Tumour Registry experience,” Medical and Pediatric Oncology, vol. 21, no. 2, pp. 111–116, 1993. View at: Google Scholar
  8. R H Jr Fitzgerald, D C Dahlin, and F H Sim, “Multiple metachronous osteogenic sarcoma. Report of twelve cases with two long-term survivors,” Journal of Bone and Joint Surgery. American Volume, vol. 55, no. 3, pp. 595–605, 1973. View at: Google Scholar
  9. C HG Price, “Multifocal osteogenic sarcoma,” The Journal of Bone and Joint Surgery. British Volume, vol. 39, pp. 524–533, 1957. View at: Google Scholar
  10. A Iavarone, K K Matthay, T M Steinkirchner, and M A Israel, “Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 9, pp. 4207–4209, 1992. View at: Publisher Site | Google Scholar
  11. P Potepan, R Luksch, G Sozzi et al., “Multifocal osteosarcoma as second tumor after childhood retinoblastoma,” Skeletal Radiology, vol. 28, no. 7, pp. 415–421, 1999. View at: Publisher Site | Google Scholar
  12. K D Hopper, R P Jr Moser, D B Haseman, D E Sweet, J E Madewell, and M J Kransdorf, “Osteosarcomatosis,” Radiology, vol. 175, no. 1, pp. 233–239, 1990. View at: Google Scholar
  13. W F Enneking and A Kagan, ““Skip” metastases in osteosarcoma,” Cancer, vol. 36, no. 6, pp. 2192–2205, 1975. View at: Google Scholar
  14. O V Batson, “The vertebral vein system,” American Journal of Roentgenology, vol. 78, pp. 195–212, 1957. View at: Google Scholar
  15. M Hatori, H Ohtani, N Yamada, M Uzuki, and S Kokubun, “Synchronous multifocal osteosarcoma with lymphatic spread in the lung: an autopsy case report,” Japanese Journal of Clinical Oncology, vol. 31, no. 11, pp. 562–566, 2001. View at: Publisher Site | Google Scholar
  16. G Bacci, A Longhi, S Ferrari et al., “Neoadjuvant chemotherapy (NC) for synchronous multifocal osteosarcoma (SMO),” in Proceedings of 37th Annual Meeting of the American Society of Clinical Oncology, San Francisco, Calif, May 2001. View at: Google Scholar
  17. J P Mahoney, S S Spanier, and J L Morris, “Multifocal osteosarcoma. A case report with review of the literature,” Cancer, vol. 44, no. 5, pp. 1897–1907, 1979. View at: Publisher Site | Google Scholar
  18. G Bacci, P Picci, S Ferrari et al., “Synchronous multifocal osteosarcoma: results in twelve patients treated with neoadjuvant chemotherapy and simultaneous resection of all involved bones,” Annals of Oncology, vol. 7, no. 8, pp. 864–866, 1996. View at: Google Scholar

Copyright © 2006 Verity A. Currall and John H. Dixon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views240
Downloads660
Citations

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.