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Sarcoma
Volume 2006, Article ID 85234, 5 pages
http://dx.doi.org/10.1155/SRCM/2006/85234
Case Report

Electroporation Therapy in Soft Tissue Sarcoma: A Potentially Effective Novel Treatment

1Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center (VUmc), De Boelelaan 1117, Amsterdam, HV 1081, The Netherlands
2Department of Medical Oncology, VU University Medical Center (VUmc), De Boelelaan 1117, Amsterdam, HV 1081, The Netherlands

Received 19 November 2005; Accepted 23 May 2006

Copyright © 2006 Remco de Bree et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Examination of the potential of electroporation therapy (EPT) in a patient with metastatic soft tissue sarcoma. Patient. A 24-year-old male who underwent extensive resection and postoperative radiotherapy for a malignant peripheral nerve sheath tumor in the right infratemporal fossa with intracranial extension and invasion of the maxillary sinus and mandible had a recurrence in the scar of his craniotomy for which he was initially treated with doxorubicin. After discontinuation of doxorubicin he developed a metastatic mass at the same site for which he was treated with electroporation therapy. Method. The subcutaneous metastasis was infiltrated with bleomycin and electroporated. Results. Gradually the tumor became increasingly necrotic and demarcated from surrounding tissue. After 10 weeks no tumor was seen anymore. The wound healed secondarily. Discussion. Intralesional bleomycin followed by EPT is potentially effective, well tolerated, and easy to perform in well accessible soft tissue sarcoma sites.