Clinical Outcomes of Intraoperative Radiation Therapy for Extremity Sarcomas

Tran, Quy N. H.; Kim, Anne C.; Gottschalk, Alexander R.; Wara, William M.; Phillips, Theodore L.; O'Donnell, Richard J.; Weinberg, Vivian; Haas-Kogan, Daphne A.

doi:https://doi.org/10.1155/SRCM/2006/91671

Sarcoma

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Research Article | Open Access

Volume 2006 | Article ID 091671 | https://doi.org/10.1155/SRCM/2006/91671

Clinical Outcomes of Intraoperative Radiation Therapy for Extremity Sarcomas

Quy N. H. Tran,¹Anne C. Kim,¹Alexander R. Gottschalk,¹William M. Wara,¹Theodore L. Phillips,¹Richard J. O'Donnell,²Vivian Weinberg,³and Daphne A. Haas-Kogan¹

Received19 May 2005

Accepted15 Dec 2005

Published06 Apr 2006

Abstract

Purpose. Radiation of extremity lesions, a key component of limb-sparing therapy, presents particular challenges, with significant risks of toxicities. We sought to explore the efficacy of intraoperative radiation therapy (IORT) in the treatment of soft tissue sarcomas of the extremities. Patients. Between 1995 and 2001, 17 patients received IORT for soft tissue sarcomas of the extremities. Indications for IORT included recurrent tumors in a previously radiated field or tumors adjacent to critical structures. Results. Gross total resections were achieved in all 17 patients. Two patients experienced locoregional relapses, six patients recurred at metastatic sites, and one patient died without recurrence. Thirty-six month estimates for locoregional control, disease free survival, and overall survival were 86%, 50%, and 78%, respectively. IORT was extremely well tolerated, with no toxicities referable to IORT. Conclusions. For patients with soft tissue sarcomas of the extremities, IORT used as a boost to EBRT provides excellent local control, with limited acute toxicities.

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Copyright © 2006 Quy N. H. Tran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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