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Sarcoma
Volume 2006 (2006), Article ID 91671, 6 pages
http://dx.doi.org/10.1155/SRCM/2006/91671
Research Article

Clinical Outcomes of Intraoperative Radiation Therapy for Extremity Sarcomas

1Department of Radiation Oncology, Comprehensive Cancer Center, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143-1708, USA
2Department of Orthopaedic Surgery, Comprehensive Cancer Center, University of California at San Francisco, 1600 Divisadero Street, 4th Floor, San Francisco, CA 94143-1708, USA
3Biostatistics Core, Comprehensive Cancer Center, University of California at San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143-1708, USA

Received 19 May 2005; Accepted 15 December 2005

Copyright © 2006 Quy N. H. Tran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P WT Pisters and R E Pollock, “Staging and prognostic factors in soft tissue sarcoma,” Seminars in Radiation Oncology, vol. 9, no. 4, pp. 307–314, 1999. View at Publisher · View at Google Scholar
  2. F L Greene, D L Page, I D Fleming, A Fritz, and C M Balch, Eds., AJCC Cancer Staging Manual, Springer, New York, NY, 6th edition, 2002.
  3. R S Benjamin, “Evidence for using adjuvant chemotherapy as standard treatment of soft tissue sarcoma,” Seminars in Radiation Oncology, vol. 9, no. 4, pp. 349–351, 1999. View at Publisher · View at Google Scholar
  4. R Heyn, M Beltangady, D Hays et al., “Results of intensive therapy in children with localized alveolar extremity rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study,” Journal of Clinical Oncology, vol. 7, no. 2, pp. 200–207, 1989. View at Google Scholar
  5. B L Hintz, K K Charyulu, W E Miller, and A Sudarsanam, “Adjuvant role of radiation in soft tissue sarcoma in adults,” Journal of Surgical Oncology, vol. 9, no. 4, pp. 329–338, 1977. View at Publisher · View at Google Scholar
  6. T J Kinsella, A S Lichter, J Miser, L Gerber, and E Glatstein, “Local treatment of Ewing's sarcoma: radiation therapy versus surgery,” Cancer Treatment Reports, vol. 68, no. 5, pp. 695–701, 1984. View at Google Scholar
  7. S A Leibel, R F Tranbaugh, W M Wara, J H Beckstead, E G Bovill, and T L Phillips, “Soft tissue sarcomas of the extremities: survival and patterns of failure with conservative surgery and postoperative irradiation compared to surgery alone,” Cancer, vol. 50, no. 6, pp. 1076–1083, 1982. View at Publisher · View at Google Scholar
  8. P WT Pisters, “Combined modality treatment of extremity soft tissue sarcomas,” Annals of Surgical Oncology, vol. 5, no. 5, pp. 464–472, 1998. View at Publisher · View at Google Scholar
  9. S A Rosenberg, J Tepper, E Glatstein et al., “The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy,” Annals of Surgery, vol. 196, no. 3, pp. 305–315, 1982. View at Publisher · View at Google Scholar
  10. “Sarcoma Meta-analysis Collaboration. Adjuvant chemotherapy for localized resectable soft-tissue sarcoma of adults: meta-analysis of individual data,” Lancet, vol. 350, no. 9092, pp. 1647–1654, 1997. View at Publisher · View at Google Scholar
  11. B O'Sullivan, J Wylie, C Catton et al., “The local management of soft tissue sarcoma,” Seminars in Radiation Oncology, vol. 9, no. 4, pp. 328–348, 1999. View at Google Scholar
  12. D A Potter, T Kinsella, E Glatstein et al., “High-grade soft tissue sarcomas of the extremities,” Cancer, vol. 58, no. 1, pp. 190–205, 1986. View at Publisher · View at Google Scholar
  13. J C Yang, A E Chang, A R Baker et al., “Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity,” Journal of Clinical Oncology, vol. 16, no. 1, pp. 197–203, 1998. View at Google Scholar
  14. M Abe and Y Shibamoto, “The usefulness of intraoperative radiation therapy in the treatment of pelvic recurrence of cervical cancer,” International Journal of Radiation Oncology Biology Physics, vol. 34, no. 2, pp. 513–514, 1996. View at Publisher · View at Google Scholar
  15. M Abe and M Takahashi, “Intraoperative radiotherapy: the Japanese experience,” International Journal of Radiation Oncology Biology Physics, vol. 7, no. 7, pp. 863–868, 1981. View at Google Scholar
  16. G E Hanks and R M Lanciano, “Intraoperative radiation therapy: cut bait or keep on fishing?” International Journal of Radiation Oncology, Biology, Physics, vol. 34, no. 2, pp. 515–517, 1996. View at Publisher · View at Google Scholar
  17. H K Kim, J M Jessup, C J Beard et al., “Locally advanced rectal carcinoma: pelvic control and morbidity following preoperative radiation therapy, resection, and intraoperative radiation therapy,” International Journal of Radiation Oncology, Biology, Physics, vol. 38, no. 4, pp. 777–783, 1997. View at Publisher · View at Google Scholar
  18. K Matsumoto, T Kakizoe, S Mikuriya, T Tanaka, I Kondo, and Y Umegaki, “Clinical evaluation of intraoperative radiotherapy for carcinoma of the urinary bladder,” Cancer, vol. 47, no. 3, pp. 509–513, 1981. View at Publisher · View at Google Scholar
  19. L L Gunderson, D M Nagorney, D C McIlrath et al., “External beam and intraoperative electron irradiation for locally advanced soft tissue sarcomas,” International Journal of Radiation Oncology, Biology, Physics, vol. 25, no. 4, pp. 647–656, 1993. View at Google Scholar
  20. V Valentini, M Balducci, F Tortoreto, A G Moranti, U De Giorgi, and G Fiorentini, “Intraoperative radiotherapy: current thinking,” European Journal of Surgical Oncology, vol. 28, no. 2, pp. 180–185, 2002. View at Publisher · View at Google Scholar
  21. D T Cromack, M M Maher, H Hoekstra, T J Kinsella, and W F Sindelar, “Are complications in intraoperative radiation therapy more frequent than in conventional treatment?” Archives of Surgery, vol. 124, no. 2, pp. 229–234, 1989. View at Google Scholar
  22. P WT Pisters, M T Ballo, M J Fenstermacher et al., “Phase I trial of preoperative concurrent doxorubicin and radiation therapy, surgical resection, and intraoperative electron-beam radiation therapy for patients with localized retroperitoneal sarcoma,” Journal of clinical oncology, vol. 21, no. 16, pp. 3092–3097, 2003. View at Publisher · View at Google Scholar
  23. M L Meurk, D A Goer, G Spalek, and T Cook, “The Mobetron: a new concept for IORT,” Frontiers of Radiation Therapy and Oncology, vol. 31, pp. 65–70, 1997. View at Google Scholar
  24. B O'Sullivan, A M Davis, R Turcotte et al., “Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial,” Lancet, vol. 359, no. 9325, pp. 2235–2241, 2002. View at Google Scholar
  25. E Y Cheng, K E Dusenbery, M R Winters, and R C Thompson, “Soft tissue sarcomas: preoperative versus postoperative radiotherapy,” Journal of Surgical Oncology, vol. 61, no. 2, pp. 90–99, 1996. View at Publisher · View at Google Scholar
  26. M M Spierer, K M Alektiar, M J Zelefsky, M F Brennan, and P G Cordiero, “Tolerance of tissue transfers to adjuvant radiation therapy in primary soft tissue sarcoma of the extremity,” International Journal of Radiation Oncology, Biology, Physics, vol. 56, no. 4, pp. 1112–1116, 2003. View at Publisher · View at Google Scholar
  27. T J Kinsella, W F Sindelar, E Lack, E Glatstein, and S A Rosenberg, “Preliminary results of a randomized study of adjuvant radiation therapy in resectable adult retroperitoneal soft tissue sarcomas,” Journal of Clinical Oncology, vol. 6, no. 1, pp. 18–25, 1988. View at Google Scholar
  28. W F Sindelar, T J Kinsella, P W Chen et al., “Intraoperative radiotherapy in retroperitoneal sarcomas. Final results of a prospective, randomized, clinical trial,” Archives of Surgery, vol. 128, no. 4, pp. 402–410, 1993. View at Google Scholar
  29. I Azinovic, R M Monge, J J Aristu et al., “Intraoperative radiotherapy electron boost followed by moderate doses of external beam radiotherapy in resected soft-tissue sarcoma of the extremities,” Radiotherapy and Oncology, vol. 67, no. 3, pp. 331–337, 2003. View at Publisher · View at Google Scholar
  30. J B Dubois, C Debrigode, M Hay et al., “Intra-operative radiotherapy in soft tissue sarcomas,” Radiotherapy and Oncology, vol. 34, no. 2, pp. 160–163, 1995. View at Publisher · View at Google Scholar
  31. M van Kampen, M J Eble, T Lehnert et al., “Correlation of intraoperatively irradiated volume and fibrosis in patients with soft-tissue sarcoma of the extremities,” International Journal of Radiation Oncology Biology Physics, vol. 51, no. 1, pp. 94–99, 2001. View at Publisher · View at Google Scholar
  32. T Lehnert, M Schwarzbach, F Willeke et al., “Intraoperative radiotherapy for primary and locally recurrent soft tissue sarcoma: morbidity and long-term prognosis,” European Journal of Surgical Oncology, vol. 26, no. suppl A, pp. S21–S24, 2000. View at Publisher · View at Google Scholar