FDG-PET Lacks Sufficient Sensitivity to Detect Myxoid Liposarcoma Spinal Metastases Detected by MRI

Schwab, Joseph H.; Healey, John H.

doi:https://doi.org/10.1155/2007/36785

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Case Report | Open Access

Volume 2007 | Article ID 036785 | https://doi.org/10.1155/2007/36785

FDG-PET Lacks Sufficient Sensitivity to Detect Myxoid Liposarcoma Spinal Metastases Detected by MRI

Joseph H. Schwab¹and John H. Healey¹

Academic Editor: David Harmon

Received26 Nov 2006

Accepted21 Mar 2007

Published23 May 2007

Abstract

Purpose. To document a case of myxoid liposarcoma in which PET scan was less sensitive than MRI in detecting spinal metastasis. Materials and Methods. The case of a 65-year-old female with a history of myxoid liposarcoma (MLS) of the thigh resected 5 years previously and now presenting with low back pain is presented. Her medical oncologist ordered an FDG-PET scan to evaluate distant recurrence. Subsequently, an MRI of her spine was obtained by her surgeon. Results. The FDG-PET scan was obtained 1 week prior to the MRI, and it did not show increased glucose uptake in the spine. Her MRI did show increased signal intensity in her lumbar spine. CT needle biopsy confirmed the lesion to be metastatic MLS. Conclusion. FDG-PET scans are utilized to detect distant recurrence of cancerous lesions. Myxoid liposarcoma has a unique propensity to metastasize to the spine. Previous reports have documented the unreliability of bone scintigraphy to diagnose these metastases. Our report demonstrates that FDG-PET may also lack the sensitivity needed to detect these lesions. We advocate total spine MRI when screening for metastases in this population when they present with back pain.

References

C. R. Antonescu, S. J. Tschernyavsky, and R. Decuseara et al., “Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases,” Clinical Cancer Research, vol. 7, no. 12, pp. 3977–3987, 2001.
View at: Google Scholar
S. H. Estourgie, G. P. Nielsen, and M. J. Ott, “Metastatic patterns of extremity myxoid liposarcoma and their outcome,” Journal of Surgical Oncology, vol. 80, no. 2, pp. 89–93, 2002.
View at: Publisher Site | Google Scholar
S. E. Kilpatrick, J. Doyon, P. F. M. Choong, F. H. Sim, and A. G. Nascimento, “The clinicopathologic spectrum of myxoid and round cell liposarcoma: a study of 95 cases,” Cancer, vol. 77, no. 8, pp. 1450–1458, 1996.
View at: Publisher Site | Google Scholar
R. Kirollos, G. Koutsoubelis, S. Ross, and S. Al Sarraj, “An unusual case of spinal metastasis from a liposarcoma,” European Journal of Surgical Oncology, vol. 22, no. 3, pp. 303–305, 1996.
View at: Publisher Site | Google Scholar
T. Ishii, T. Ueda, A. Myoui, N. Tamai, N. Hosono, and H. Yoshikawa, “Unusual skeletal metastases from myxoid liposarcoma only detectable by MR imaging,” European Radiology, vol. 13, supplement 6, pp. L185–L191, 2003.
View at: Publisher Site | Google Scholar
J. S. Khurana, D. I. Rosenthal, A. E. Rosenberg, and H. J. Mankin, “Skeletal metastases in liposarcoma detectable only by magnetic resonance imaging,” Clinical Orthopaedics and Related Research, no. 243, pp. 204–207, 1989.
View at: Google Scholar

Copyright

Copyright © 2007 Joseph H. Schwab and John H. Healey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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