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Sarcoma
Volume 2007, Article ID 95628, 7 pages
http://dx.doi.org/10.1155/2007/95628
Research Article

High VEGF with Rapid Growth and Early Metastasis in a Mouse Osteosarcoma Model

Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA

Received 27 March 2007; Accepted 19 October 2007

Academic Editor: Irene Andrulis

Copyright © 2007 Shang-You Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Rosen, S. Suwansirikul, C. Kwon et al., “High dose methotrexate with citrovorum factor rescue and adriamycin in childhood osteogenic sarcoma,” Cancer, vol. 33, no. 4, pp. 1151–1163, 1974. View at Publisher · View at Google Scholar
  2. B. L. Coomber, J. Denton, A. Sylvestre, and S. Kruth, “Blood vessel density in canine osteosarcoma,” Canadian Journal of Veterinary Research, vol. 62, no. 3, pp. 199–204, 1998. View at Google Scholar
  3. J. Folkman, “Angiogenesis in cancer, vascular, rheumatoid and other disease,” Nature Medicine, vol. 1, no. 1, pp. 27–31, 1995. View at Publisher · View at Google Scholar
  4. J. Folkman, “Role of angiogenesis in tumor growth and metastasis,” Seminars in Oncology, vol. 29, no. 6, supplement 16, pp. 15–18, 2002. View at Google Scholar
  5. G. McMahon, “VEGF receptor signaling in tumor angiogenesis,” The Oncologist, vol. 5, supplement 1, pp. 3–10, 2000. View at Publisher · View at Google Scholar
  6. D. W. Leung, G. Cachianes, W.-J. Kuang, D. V. Goeddel, and N. Ferrara, “Vascular endothelial growth factor is a secreted angiogenic mitogen,” Science, vol. 246, no. 4935, pp. 1306–1309, 1989. View at Publisher · View at Google Scholar
  7. Y. H. Lee, T. Tokunaga, Y. Oshika et al., “Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma,” European Journal of Cancer, vol. 35, no. 7, pp. 1089–1093, 1999. View at Publisher · View at Google Scholar
  8. S.-Y. Yang, B. Wu, L. Mayton, C. H. Evans, P. D. Robbins, and P. H. Wooley, “IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model,” Inflammation Research, vol. 51, no. 7, pp. 342–350, 2002. View at Publisher · View at Google Scholar
  9. E. Ben-Josef, S.-Y. Yang, T. H. Ji et al., “Hormone-refractory prostate cancer cells express functional follicle-stimulating hormone receptor (FSHR),” The Journal of Urology, vol. 161, no. 3, pp. 970–976, 1999. View at Publisher · View at Google Scholar
  10. S.-Y. Yang, B. Wu, L. Mayton et al., “Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis,” Gene Therapy, vol. 11, no. 5, pp. 483–491, 2004. View at Publisher · View at Google Scholar
  11. PE Applied Biosystems, “TaqMan cytokine gene expression plate I—protocol,” 1998, The PerkinElmer, Foster City, Calif, USA. View at Google Scholar
  12. N. Weidner, P. R. Carroll, J. Flax, W. Blumenfeld, and J. Folkman, “Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma,” American Journal of Pathology, vol. 143, no. 2, pp. 401–409, 1993. View at Google Scholar
  13. N. Weidner, J. P. Semple, W. R. Welch, and J. Folkman, “Tumor angiogenesis and metastasis—correlation in invasive breast carcinoma,” The New England Journal of Medicine, vol. 324, no. 1, pp. 1–8, 1991. View at Google Scholar
  14. D. Hanahan and J. Folkman, “Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis,” Cell, vol. 86, no. 3, pp. 353–364, 1996. View at Publisher · View at Google Scholar
  15. K. Suzuki, N. Hayashi, Y. Miyamoto et al., “Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma,” Cancer Research, vol. 56, no. 13, pp. 3004–3009, 1996. View at Google Scholar
  16. G. Holzer, A. Obermair, M. Koschat, O. Preyer, R. Kotz, and K. Trieb, “Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with malignant bone tumors,” Medical and Pediatric Oncology, vol. 36, no. 6, pp. 601–604, 2001. View at Publisher · View at Google Scholar
  17. M. Kaya, T. Wada, T. Akatsuka et al., “Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis,” Clinical Cancer Research, vol. 6, no. 2, pp. 572–577, 2000. View at Google Scholar
  18. C. Barrios, J. S. Castresana, J. Ruiz, and A. Kreicbergs, “Amplification of c-myc oncogene and absence of c-Ha-ras point mutation in human bone sarcoma,” Journal of Orthopaedic Research, vol. 11, no. 4, pp. 556–563, 1993. View at Publisher · View at Google Scholar
  19. G. Gamberi, M. S. Benassi, T. Bohling et al., “C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression,” Oncology, vol. 55, no. 6, pp. 556–563, 1998. View at Publisher · View at Google Scholar
  20. F. Pompetti, P. Rizzo, R. M. Simon et al., “Oncogene alterations in primary, recurrent, and metastatic human bone tumors,” Journal of Cellular Biochemistry, vol. 63, no. 1, pp. 37–50, 1996. View at Publisher · View at Google Scholar
  21. S. van den Berg, H. J. Rahmsdorf, P. Herrlich, and B. Kaina, “Overexpression of c-fos increases recombination frequency in human osteosarcoma cells,” Carcinogenesis, vol. 14, no. 5, pp. 925–928, 1993. View at Publisher · View at Google Scholar
  22. J.-X. Wu, P. M. Carpenter, C. Gresens et al., “The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas,” Oncogene, vol. 5, no. 7, pp. 989–1000, 1990. View at Google Scholar
  23. M. D. Cole and S. B. McMahon, “The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation,” Oncogene, vol. 18, no. 19, pp. 2916–2924, 1999. View at Publisher · View at Google Scholar
  24. C. Khanna, J. Prehn, C. Yeung, J. Caylor, M. Tsokos, and L. Helman, “An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential,” Clinical and Experimental Metastasis, vol. 18, no. 3, pp. 261–271, 2000. View at Publisher · View at Google Scholar
  25. H. H. Luu, Q. Kang, J. K. Park et al., “An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis,” Clinical and Experimental Metastasis, vol. 22, no. 4, pp. 319–329, 2005. View at Publisher · View at Google Scholar