Immunohistochemical Estimates of Angiogenesis, Proliferative Activity, p53 Expression, and Multiple Drug Resistance Have No Prognostic Impact in Osteosarcoma: A Comparative Clinicopathological Investigation
Table 1
Clinicopathological data of 117 patients with primary osteosarcoma.
N
Sex
Women
41
Men
76
Age
Mean (years)
23.8
SD (years)
16.6
Range (years)
4–74
Tumor site
Humerus and radius
12
Pelvis
10
Femur
66
Tibia
21
Fibula
6
Tarsal bones
2
Extent of tumor
Intraosseous
6
+ Cortical breakthrough
16
+ Soft tissue extension
95
Type of osteosarcoma
Classical high grade
98
Other types
19
Largest tumor diametera
Mean (cm)
10.1
SD (cm)
3.9
Range (cm)
3–20
Diagnostic delayb
Mean (months)
5.3
SD (months)
3.9
Range (months)
1–36
Type of surgical treatment
None
5
Tumor resection
26
Amputation
86
Histological radicality of surgeryc
Intralesional resection
4
Marginal resection
5
Wide resection(radical)
49
Amputation (radical)
54
Chemotherapyd
+ Preoperative chemotherapy
46
Preoperative chemotherapy
63
+ Other kind of chemotherapy
8
Radiation therapye
+ Radiation therapy
7
Radiation therapy
110
Clinical response to primary treatment
Complete clinical response
107
Persistent disease
10
Histological response to preoperative chemotherapy
100% tumor necrosis
6
90% tumor necrosis
11
50–90% tumor necrosis
14
50% tumor necrosis
10
No necrosis
5
Recurrent diseasef
No recurrence
51
+ Recurrence
56
Persistent disease
10
Survival statusg
Survivors
58
Death caused by OS
58
Death from unrelated disease
1
diameter not known for 3 patients. delay was estimated from the anamnestic informations given in the clinical records and was unknown for 19 patients. patients did not receive surgical treatment, but were by own wish treated by either chemotherapy and/or radiation therapy alone/combined or refused any treatment. patient received chemotherapy as the only treatment modality and did not wish the subsequent surgery, whereas 7 other patients received chemotherapy as adjuvant to other treatment. patients received radiation therapy as the only treatment. ecurrence status at the closure of the study. status at the closure of the study.
