Immunohistochemical Estimates of Angiogenesis, Proliferative Activity, p53 Expression, and Multiple Drug Resistance Have No Prognostic Impact in Osteosarcoma: A Comparative Clinicopathological Investigation

Table 6

Relationships between multiple drug resistance (Pgp expression) in pre-chemotherapy biopsies of 46 osteosarcomas and histological response (necrosis) in surgical specimens^a. P value^b=.53.

Pre-chemotherapy MDR-score^a	Tumor necrosis		∑
	<90%	≥90%
≥2	12	7	19
<2	16	11	27
∑	28	18	46

^aMDR-score ≥2 indicates resistance to chemotherapy.
^bFisher’s exact test.