Case Report

Ifosfamide May Be Safely Used in Patients with End Stage Renal Disease on Hemodialysis

Table 2

Proposed plan for nonoliguric patients with ESRD on dialysis receiving ifosfamide.

Day 1Admit patient in the afternoon
Forced diuresis:
   Furosemide 200 mg IVP over 1 hour
   Match urine output with D5 + 0.45%NS
   (if patient oliguric/anuric, furosemide, Mesna, and IV fluids are not needed)
Ifosfamide 1-2 g/m2 + Mesna, starting ifosfamide at 4–6 PM
Day 2HD in the AM (10–12 hrs after chemotherapy)
Repeat furosemide and IV fluids as above
Ifosfamide + Mesna, starting ifosfamide at 4–6 PM