Synergism of Heat Shock Protein 90 and Histone Deacetylase Inhibitors in Synovial Sarcoma
Figure 1
Effect of 17-AAG and MS-275 in combination on SYO-1 synovial sarcoma monolayer cultures. Cell survival at (a) 24 hours and (b) 48 hours for drugs combined at a set ratio of 2 parts 17-AAG to 5 parts MS-275. MTT cell proliferation assays were performed for the indicated doses, and survival is plotted relative to vehicle control. Corresponding combination indices are shown for (c) 24 and (d) 48 hours, where values below 1 indicate synergistic drug interactions. Error bars represent 95% confidence intervals. Combination indices were calculated using the Chou and Talalay Median Dose Method (not applicable at low doses where effective cell killing relative to control cell death was not observed).
