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Volume 2010, Article ID 353679, 3 pages
Case Report

Recurrent Endometrial Stromal Sarcoma: Treatment with a Progestin and Gonadotropin Releasing Hormone Agonist

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Irvine College of Medicine, Orange, CA 92868, USA

Received 2 September 2009; Revised 24 March 2010; Accepted 8 April 2010

Academic Editor: Michael Leahy

Copyright © 2010 Nefertiti Chianti duPont and Philip John DiSaia. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Endometrial stromal sarcoma (ESS) formerly classified as low-grade endometrial stromal sarcoma is a rare uterine malignancy with a good prognosis despite a tendency to recur. Primary surgical management for ESS includes total abdominal hysterectomy and bilateral salpingo-oophorectomy. Patients with ESS have long disease-free survival rates when treated with primary surgical therapy, but nearly fifty percent of these patients will recur. We present the case of a patient with recurrent ESS who had an excellent response to combined therapy with megestrol and leuprolide.