Molecular Characterization of Putative Chordoma Cell Lines
Figure 5
Chromosome 9p21.3 region from array CGH analysis of U-CH1 (a) and U-CH2 (b) cell lines. Both cell lines show loss of the 9p21.3 region encompassing CDKNA2, encoding the cyclin dependent kinase inhibitor p16, MTAP, encoding methylthioadenosine phosphatase, and for U-CH2, DMRTA1, encoding the transcription factor DMRT-family A1 protein. Each dot represents the copy number for the array probe for that region, and a line shows the copy number averaged across the region. Relative signal intensity values are shown on the y-axis; threshold log2 ratio of .2 or .6 was used for gain or large gain, and −.2 and −1 were used for loss and large loss.
