Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival

Table 2

Tumor expression of PDGFs and PDGFRs and their prediction for disease-specific survival in patients with nongastrointestinal stromal tumor soft-tissue sarcoma in the total material (univariate analyses; log-rank test, 𝑛=249) and in subgroups with wide and nonwide resection margins (univariate analyses; log-rank test, 𝑛=108 and 141, resp.).

Marker expression	Total material					Wide resection margins					Nonwide resection margins
	Patients; (𝑛)	Patients; (%)	Median survival; (months)	5-Year survival; (%)	𝑃	Patients; (𝑛)	Patients; (%)	Median survival; (months)	5-Year survival; (%)	𝑃	Patients; (𝑛)	Patients; (%)	Median survival; (months)	5-Year survival; (%)	𝑃
PDGF-A
Low	99	40	52	47	.253	47	44	NR	65	.190	52	37	18	29	.985
High	138	55	41	46		60	56	127	59		78	56	23	36
Missing	12	5				1	1				11	8
PDGF-B
Low	78	31	62	51	.117	32	30	NR	77	.007	46	33	25	32	.876
High	159	64	38	44		74	69	120	54		85	60	21	35
Missing	12	5				2	2				10	7
PDGF-C
Low	63	25	57	48	.226	25	23	NR	70	.148	38	27	26	33	.434
High	173	70	37	45		78	72	NR	59		95	67	15	32
Missing	13	5				5	5				8	6
PDGF-D
Low	158	63	75	51	.095	78	72	NR	67	.029	80	57	21	34	.606
High	81	33	31	37		27	25	39	46		54	38	15	33
Missing	10	4				3	3				7	5
PDGFR-α
Low	139	56	91	54	.004	73	68	NR	71	.001	66	47	25	35	.924
High	96	39	27	35		34	32	39	42		62	44	15	32
Missing	14	6				1	1				13	9
PDGFR-β
Low	183	74	63	51	.047	88	82	NR	67	.022	95	67	23	35	.781
High	48	19	22	33		17	16	31	35		31	22	11	32
Missing	18	7				3	3				15	11
PDGF-B & PDGFR-α
Low	64	26	NR	54	.020	29	27	NR	78	.001	35	25	25	33	.798
Intermediate	88	35	75	50		46	43	NR	65		42	30	23	33
High	82	33	26	35		31	29	32	40		51	36	16	33
Missing	15	6				2	2				13	9

Abbreviations: PDGF: platelet-derived growth factor; PDGFR: platelet-derived growth factor receptor; NR: not reached.