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Sarcoma
Volume 2011, Article ID 231789, 7 pages
http://dx.doi.org/10.1155/2011/231789
Research Article

Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma

1Division of Medical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9
2Division of Medical Oncology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada M5G 1Z5
3Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9
4University Musculoskeletal Oncology Unit, Division of Orthopaedic Surgery, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada M5G 1Z5
5Department of Orthopedic Surgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada M5G 1X8
6Department of Pathology, Mount Sinai Hospital, Toronto, ON, Canada M5G 1Z5
7Division of Hematology/Oncology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8

Received 30 August 2010; Revised 1 February 2011; Accepted 15 February 2011

Academic Editor: Ajay Puri

Copyright © 2011 H. Al-Hussaini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. G. J. Weiss, “Malignant soft tissue tumors of uncertain type,” in Enzinger and Weiss's Soft Tissue Tumors, S. W. Weis and J. R. Goldblum, Eds., pp. 1483–1571, C. V. Mosby, St. Louis, Mo, USA, 2001. View at Google Scholar
  2. R. Ladenstein, J. Treuner, E. Koscielniak et al., “Synovial sarcoma of childhood and adolescence: report of the German CWS- 81 study,” Cancer, vol. 71, no. 11, pp. 3647–3655, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. A. S. Pappo, J. Fontanesi, X. Luo et al., “Synovial sarcoma in children and adolescents: the St Jude Children's research hospital experience,” Journal of Clinical Oncology, vol. 12, no. 11, pp. 2360–2366, 1994. View at Google Scholar · View at Scopus
  4. R. J. Andrassy, M. F. Okcu, S. Despa, and R. B. Raney, “Synovial sarcoma in children: surgical lessons from a single institution and review of the literature,” Journal of the American College of Surgeons, vol. 192, no. 3, pp. 305–313, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. M. F. Okcu, M. Munsell, J. Treuner et al., “Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome,” Journal of Clinical Oncology, vol. 21, no. 8, pp. 1602–1611, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. I. B. Brecht, A. Ferrari, C. Int-Veen et al., “Grossly-resected synovial sarcoma treated by the German and Italian pediatric soft tissue sarcoma cooperative groups: discussion on the role of adjuvant therapies,” Pediatric Blood and Cancer, vol. 46, no. 1, pp. 11–17, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Guillou, J. Benhattar, F. Bonichon et al., “Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis,” Journal of Clinical Oncology, vol. 22, no. 20, pp. 4040–4050, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. S. I. Hajdu, M. H. Shiu, and J. G. Fortner, “Tendosynovial sarcoma. A clinicopathological study of 136 cases,” Cancer, vol. 39, no. 3, pp. 1201–1217, 1977. View at Google Scholar · View at Scopus
  9. M. Trassard, V. Le Doussal, K. Hacène et al., “Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients,” Journal of Clinical Oncology, vol. 19, no. 2, pp. 525–534, 2001. View at Google Scholar · View at Scopus
  10. T. Hasegawa, R. Yokoyama, Y. Matsuno, T. Shimoda, and S. Hirohashi, “Prognostic significance of histologic grade and nuclear expression of β-catenin in synovial sarcoma,” Human Pathology, vol. 32, no. 3, pp. 257–263, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Singer, E. H. Baldini, G. D. Demetri, J. A. Fletcher, and J. M. Corson, “Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival,” Journal of Clinical Oncology, vol. 14, no. 4, pp. 1201–1208, 1996. View at Google Scholar · View at Scopus
  12. A. Ferrari, M. Casanova, M. Massimino et al., “Synovial sarcoma: report of a series of 25 consecutive children from a single institution,” Medical and Pediatric Oncology, vol. 32, no. 1, pp. 32–37, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. R. J. Canter, L. X. Qin, R. G. Maki, M. F. Brennan, M. Ladanyi, and S. Singer, “A synovial sarcoma-specific preoperative nomogram supports a survival benefit to ifosfamide-based chemotherapy and improves risk stratification for patients,” Clinical Cancer Research, vol. 14, no. 24, pp. 8191–8197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. F. C. Eilber, M. F. Brennan, F. R. Eilber et al., “Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma,” Annals of Surgery, vol. 246, no. 1, pp. 105–113, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Italiano, N. Penel, Y. M. Robin et al., “Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group,” Annals of Oncology, vol. 20, no. 3, pp. 425–430, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. J. J. Lewis, C. R. Antonescu, D. H. Y. Leung et al., “Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity,” Journal of Clinical Oncology, vol. 18, no. 10, pp. 2087–2094, 2000. View at Google Scholar · View at Scopus
  17. E. Palmerini, E. L. Staals, M. Alberghini et al., “Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution,” Cancer, vol. 115, no. 13, pp. 2988–2998, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Le Cesne, M. Van Glabbeke, P. J. Woll et al., “The end of adjuvant chemotherapy era with doxorubicin-based regimen in resected high-grade soft tissue sarcoma(STS): pooled analysis of the two STBSG-EORTC phase III clinical trials,” Journal of Clinical Oncology, vol. 26, supplement, 2008, Abstract 10525. View at Google Scholar
  19. A. S. Pappo, M. Devidas, J. Jenkins et al., “Phase II trial of neoadjuvant vincristine, ifosfamide, and doxorubicin with granulocyte colony-stimulating factor support in children and adolescents with advanced-stage nonrhabdomyosarcomatous soft tissue sarcomas: a pediatric oncology group study,” Journal of Clinical Oncology, vol. 23, no. 18, pp. 4031–4038, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. E. A. Eisenhauer, P. Therasse, J. Bogaerts et al., “New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1),” European Journal of Cancer, vol. 45, no. 2, pp. 228–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. W. F. Enneking, S. S. Spanier, and M. Goodman, “A system for the surgical staging of musculoskeletal sarcoma,” Clinical Orthopaedics and Related Research, vol. 153, pp. 106–120, 1980. View at Google Scholar · View at Scopus
  22. M. Schemper and T. L. Smith, “A note on quantifying follow-up in studies of failure time,” Controlled Clinical Trials, vol. 17, no. 4, pp. 343–346, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Palmerini, L. Zanella et al., “Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution,” Cancer, vol. 115, no. 13, pp. 2988–2998, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. B. A. Guadagnolo, G. K. Zagars, M. T. Ballo et al., “Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 69, no. 4, pp. 1173–1180, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Frustaci, F. Gherlinzoni, A. De Paoli et al., “Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the italian randomized cooperative trial,” Journal of Clinical Oncology, vol. 19, no. 5, pp. 1238–1247, 2001. View at Google Scholar · View at Scopus
  26. S. Frustaci, A. De Paoli, E. Bidoli et al., “Ifosfamide in the adjuvant therapy of soft tissue sarcomas,” Oncology, vol. 65, no. 2, pp. 80–84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Pervaiz, N. Colterjohn, F. Farrokhyar, R. Tozer, A. Figueredo, and M. Ghert, “A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma,” Cancer, vol. 113, no. 3, pp. 573–581, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. B. C. Widemann, F. M. Balis, B. Kempf-Bielack et al., “High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma: incidence, treatment, and outcome,” Cancer, vol. 100, no. 10, pp. 2222–2232, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Rosen, C. Forscher, S. Lowenbraun et al., “Synovial sarcoma: uniform response of metastases to high dose ifosfamide,” Cancer, vol. 73, no. 10, pp. 2506–2511, 1994. View at Publisher · View at Google Scholar · View at Scopus
  30. F. P. Worden, J. M. G. Taylor, J. S. Biermann et al., “Randomized phase II evaluation of 6 g/m of ifosfamide plus doxorubicin and granulocyte colony-stimulating factor (G-CSF) compared with 12 g/m of ifosfamide plus doxorubicin and G-CSF in the treatment of poor-prognosis soft tissue sarcoma,” Journal of Clinical Oncology, vol. 23, no. 1, pp. 105–112, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. S. J. Gwyther, O. S. Nielsen, I. R. Judson, M. Van Glabbeke, and J. Verweij, “Radiologist review versus group peer review of claimed responses in a phase II study on high-dose ifosfamide in advanced soft tissue sarcomas of the adult: a study of the EORTC soft tissue and bone sarcoma group,” Anti-Cancer Drugs, vol. 11, no. 6, pp. 433–437, 2000. View at Publisher · View at Google Scholar
  32. A. J. Spillane, R. A'Hern, I. R. Judson, C. Fisher, and J. M. Thomas, “Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment,” Journal of Clinical Oncology, vol. 18, no. 22, pp. 3794–3803, 2000. View at Google Scholar · View at Scopus
  33. R. J. Canter, S. R. Martinez, R. M. Tamurian et al., “Radiographic and histologic response to neoadjuvant radiotherapy in patients with soft tissue sarcoma,” Annals of Surgical Oncology, pp. 1–7, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Stacchiotti, P. Collini, A. Messina et al., “High-grade soft-tissue sarcomas: tumor response assessment—pilot study to assess the correlation between radiologic and pathologic response by using RECIST and Choi criteria,” Radiology, vol. 251, no. 2, pp. 447–456, 2009. View at Publisher · View at Google Scholar
  35. S. M. Schuetze, L. H. Baker, R. S. Benjamin, and R. Canettac, “Selection of response criteria for clinical trials of sarcoma treatment,” Oncologist, vol. 13, supplement 2, pp. 32–40, 2008. View at Publisher · View at Google Scholar
  36. C. C. Jaffe, “Response assessment in clinical trials: implications for sarcoma clinical trial design,” Oncologist, vol. 13, no. 2, pp. 14–18, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Stojadinovic, D. H. Y. Leung, A. Hoos, D. P. Jaques, J. J. Lewis, and M. F. Brennan, “Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas,” Annals of Surgery, vol. 235, no. 3, pp. 424–434, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Pradhan, Y. C. Cheung, R. J. Grimer et al., “Does the method of treatment affect the outcome in soft-tissue sarcomas of the adductor compartment?” Journal of Bone and Joint Surgery. Series B, vol. 88, no. 11, pp. 1480–1486, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. J. J. Lewis, D. Leung, M. Heslin, J. M. Woodruff, and M. F. Brennan, “Association of local recurrence with subsequent survival in extremity soft tissue sarcoma,” Journal of Clinical Oncology, vol. 15, no. 2, pp. 646–652, 1997. View at Google Scholar · View at Scopus
  40. F. C. Eilber, G. Rosen, S. D. Nelson et al., “High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality,” Annals of Surgery, vol. 237, no. 2, pp. 218–226, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. A. T. Stotter, R. P. A'Hern, C. Fisher, A. F. Mott, M. E. Fallowfield, and G. Westbury, “The influence of local recurrence of extremity soft tissue sarcoma on metastasis and survival,” Cancer, vol. 65, no. 5, pp. 1119–1129, 1990. View at Google Scholar · View at Scopus
  42. C. S. Trovik and H. C. F. Bauer, “Local recurrence of soft tissue sarcoma a risk factor for late metastases: 379 patients followed for 0.5–20 years,” Acta Orthopaedica Scandinavica, vol. 65, no. 5, pp. 553–558, 1994. View at Google Scholar · View at Scopus
  43. P. C. Ferguson, A. M. Griffin, B. O'Sullivan et al., “Bone invasion in extremity soft-tissue sarcoma: impact on disease outcomes,” Cancer, vol. 106, no. 12, pp. 2692–2700, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. D. M. Panicek, S. D. Go, J. H. Healey, D. H. Y. Leung, M. F. Brennan, and J. J. Lewis, “Soft-tissue sarcoma involving bone or neurovascular structures: MR imaging prognostic factors,” Radiology, vol. 205, no. 3, pp. 871–875, 1997. View at Google Scholar · View at Scopus
  45. M. A. Ghert, A. M. Davis, A. M. Griffin et al., “The surgical and functional outcome of limb-salvage surgery with vascular reconstruction for soft tissue sarcoma of the extremity,” Annals of Surgical Oncology, vol. 12, no. 12, pp. 1102–1110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. C. H. Chui, S. L. Spunt, T. Liu et al., “Is reexcision in pediatric nonrhabdomyosarcoma soft tissue sarcoma necessary after an initial unplanned resection?” Journal of Pediatric Surgery, vol. 37, no. 10, pp. 1424–1429, 2002. View at Publisher · View at Google Scholar
  47. W. H. B. Wallace, R. A. Anderson, and D. S. Irvine, “Fertility preservation for young patients with cancer: who is at risk and what can be offered?” Lancet Oncology, vol. 6, no. 4, pp. 209–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. M. E. Fallat and J. Hutter, “Preservation of fertility in pediatric and adolescent patients with cancer,” Pediatrics, vol. 121, no. 5, pp. e1461–e1469, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. S. E. Lipshultz, J. A. Alvarez, and R. E. Scully, “Anthracycline associated cardiotoxicity in survivors of childhood cancer,” Heart, vol. 94, no. 4, pp. 525–533, 2008. View at Publisher · View at Google Scholar · View at Scopus