Research Article

miRNA Profiling: How to Bypass the Current Difficulties in the Diagnosis and Treatment of Sarcomas

Figure 7

Rhabdomyosarcoma miRNA signatures were consistent with their molecular alterations. (a) This supervised hierarchical clustering only conserved miRNA differently expressed in the different subtypes of RMS following an ANOVA ( 𝑃 < . 0 3 ). Each row represents the relative levels of expression for each miRNA, and each column shows the expression levels for each sample. The red or green colour indicates relatively high or low expression, respectively, while grey squares indicate no expressed miRNA. (b) Principal component analysis of RMS tumours as a tool to determine the potential tumour response to treatment. RQ values of the ten selected miRNAs for each tumour were corrected by the coefficients determined in (a), as described in Section 2.6.
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(a)
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(b)